Identification |
HMDB Protein ID
| HMDBP12086 |
Secondary Accession Numbers
| None |
Name
| Kit ligand |
Synonyms
|
- Hematopoietic growth factor KL
- Mast cell growth factor
- Stem cell factor
- c-Kit ligand
- MGF
- SCF
|
Gene Name
| KITLG |
Protein Type
| Unknown |
Biological Properties |
General Function
| Not Available |
Specific Function
| Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. |
Pathways
|
- Hematopoietic cell lineage
- MAPK signaling pathway
- Melanogenesis
- Phospholipase D signaling pathway
- PI3K-Akt signaling pathway
- Rap1 signaling pathway
- Ras signaling pathway
|
Reactions
| Not Available |
GO Classification
|
Biological Process |
ectopic germ cell programmed cell death |
extrinsic apoptotic signaling pathway in absence of ligand |
negative regulation of mast cell apoptotic process |
neural crest cell migration |
positive regulation of hematopoietic stem cell proliferation |
positive regulation of leukocyte migration |
positive regulation of mast cell proliferation |
positive regulation of melanocyte differentiation |
positive regulation of myeloid leukocyte differentiation |
positive regulation of cell proliferation |
negative regulation of apoptotic process |
cell adhesion |
positive regulation of peptidyl-tyrosine phosphorylation |
male gonad development |
positive regulation of Ras protein signal transduction |
positive regulation of MAP kinase activity |
embryonic hemopoiesis |
ovarian follicle development |
Cellular Component |
cytoskeleton |
cytoplasm |
filopodium |
plasma membrane |
lamellipodium |
extracellular space |
integral to membrane |
Molecular Function |
stem cell factor receptor binding |
growth factor activity |
cytokine activity |
|
Cellular Location
|
Not Available
|
Gene Properties |
Chromosome Location
| Not Available |
Locus
| Not Available |
SNPs
| Not Available |
Gene Sequence
|
Not Available
|
Protein Properties |
Number of Residues
| 273 |
Molecular Weight
| 30712.01 |
Theoretical pI
| 5.558 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
Not Available
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| P21581 |
UniProtKB/Swiss-Prot Entry Name
| SCF_RAT |
PDB IDs
|
Not Available |
GenBank Gene ID
| Not Available |
GeneCard ID
| Not Available |
GenAtlas ID
| Not Available |
HGNC ID
| Not Available |
References |
General References
| - Martin FH, Suggs SV, Langley KE, Lu HS, Ting J, Okino KH, Morris CF, McNiece IK, Jacobsen FW, Mendiaz EA, et al.: Primary structure and functional expression of rat and human stem cell factor DNAs. Cell. 1990 Oct 5;63(1):203-11. [PubMed:2208279 ]
- Lu HS, Clogston CL, Wypych J, Fausset PR, Lauren S, Mendiaz EA, Zsebo KM, Langley KE: Amino acid sequence and post-translational modification of stem cell factor isolated from buffalo rat liver cell-conditioned medium. J Biol Chem. 1991 May 5;266(13):8102-7. [PubMed:1708771 ]
- Zsebo KM, Wypych J, McNiece IK, Lu HS, Smith KA, Karkare SB, Sachdev RK, Yuschenkoff VN, Birkett NC, Williams LR, et al.: Identification, purification, and biological characterization of hematopoietic stem cell factor from buffalo rat liver--conditioned medium. Cell. 1990 Oct 5;63(1):195-201. doi: 10.1016/0092-8674(90)90300-4. [PubMed:2208278 ]
|