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Identification
HMDB Protein ID HMDBP12091
Secondary Accession Numbers None
Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
Synonyms
  1. Phosphoinositide phospholipase C-zeta-1
  2. Phospholipase C-zeta-1
  3. PLC-zeta-1
Gene Name PLCZ1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.
Pathways
  • Calcium signaling pathway
  • Inositol phosphate metabolism
  • Oocyte meiosis
  • Phosphatidylinositol signaling system
  • Thyroid hormone signaling pathway
Reactions Not Available
GO Classification
Biological Process
multicellular organismal development
lipid catabolic process
egg activation
calcium ion transport
intracellular signal transduction
Cellular Component
cytosol
perinuclear region of cytoplasm
nucleus
Molecular Function
phosphatidylinositol phospholipase C activity
calcium ion binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 640
Molecular Weight 74550.91
Theoretical pI 7.688
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q95JS1
UniProtKB/Swiss-Prot Entry Name PLCZ1_MACFA
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Cox LJ, Larman MG, Saunders CM, Hashimoto K, Swann K, Lai FA: Sperm phospholipase Czeta from humans and cynomolgus monkeys triggers Ca2+ oscillations, activation and development of mouse oocytes. Reproduction. 2002 Nov;124(5):611-23. [PubMed:12416999 ]
  2. Osada N, Hida M, Kusuda J, Tanuma R, Hirata M, Suto Y, Hirai M, Terao K, Sugano S, Hashimoto K: Cynomolgus monkey testicular cDNAs for discovery of novel human genes in the human genome sequence. BMC Genomics. 2002 Dec 23;3(1):36. doi: 10.1186/1471-2164-3-36. Epub 2002 Dec 23. [PubMed:12498619 ]