| Identification |
|---|
| HMDB Protein ID
| HMDBP12095 |
| Secondary Accession Numbers
| None |
| Name
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 |
| Synonyms
|
- Phosphoinositide phospholipase C-zeta-1
- Phospholipase C-zeta-1
- PLC-zeta-1
|
| Gene Name
| PLCZ1 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. |
| Pathways
|
- Calcium signaling pathway
- Inositol phosphate metabolism
- Oocyte meiosis
- Phosphatidylinositol signaling system
- Thyroid hormone signaling pathway
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| multicellular organismal development |
| elevation of cytosolic calcium ion concentration |
| positive regulation of cytosolic calcium ion concentration involved in egg activation |
| lipid catabolic process |
| egg activation |
| calcium ion transport |
| phosphatidylinositol-mediated signaling |
| Cellular Component |
| cytosol |
| sperm head |
| cytoplasm |
| nucleolus |
| perinuclear region of cytoplasm |
| nucleus |
| nucleoplasm |
| pronucleus |
| Molecular Function |
| phosphatidylinositol-3-phosphate binding |
| phosphatidylinositol-5-phosphate binding |
| phosphatidylinositol phospholipase C activity |
| phosphatidylinositol-4,5-bisphosphate binding |
| phospholipase C activity |
| calcium ion binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 645 |
| Molecular Weight
| 74314.66 |
| Theoretical pI
| 5.416 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q5FX52 |
| UniProtKB/Swiss-Prot Entry Name
| PLCZ1_RAT |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Ito M, Shikano T, Oda S, Horiguchi T, Tanimoto S, Awaji T, Mitani H, Miyazaki S: Difference in Ca2+ oscillation-inducing activity and nuclear translocation ability of PLCZ1, an egg-activating sperm factor candidate, between mouse, rat, human, and medaka fish. Biol Reprod. 2008 Jun;78(6):1081-90. doi: 10.1095/biolreprod.108.067801. Epub 2008 Mar 5. [PubMed:18322275 ]
|
