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Identification
HMDB Protein ID HMDBP12096
Secondary Accession Numbers None
Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
Synonyms
  1. PLC-85
  2. Phosphoinositide phospholipase C-delta-4
  3. Phospholipase C-delta-2
  4. Phospholipase C-delta-4
  5. PLC-delta-2
  6. PLC-delta-4
Gene Name PLCD4
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation (By similarity).
Pathways
  • AGE-RAGE signaling pathway in diabetic complications
  • Calcium signaling pathway
  • Inositol phosphate metabolism
  • Phosphatidylinositol signaling system
  • Thyroid hormone signaling pathway
Reactions Not Available
GO Classification
Biological Process
lipid catabolic process
phosphatidylinositol metabolic process
acrosome reaction
intracellular signal transduction
Cellular Component
endoplasmic reticulum
nucleus
membrane
Molecular Function
G-protein alpha-subunit binding
phosphatidylinositol phospholipase C activity
calcium ion binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 791
Molecular Weight 90580.0
Theoretical pI 5.241
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P21671
UniProtKB/Swiss-Prot Entry Name PLCD4_BOVIN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Meldrum E, Katan M, Parker P: A novel inositol-phospholipid-specific phospholipase C. Rapid purification and characterization. Eur J Biochem. 1989 Jul 1;182(3):673-7. doi: 10.1111/j.1432-1033.1989.tb14878.x. [PubMed:2753038 ]
  2. Irino Y, Cho H, Nakamura Y, Nakahara M, Furutani M, Suh PG, Takenawa T, Fukami K: Phospholipase C delta-type consists of three isozymes: bovine PLCdelta2 is a homologue of human/mouse PLCdelta4. Biochem Biophys Res Commun. 2004 Jul 23;320(2):537-43. doi: 10.1016/j.bbrc.2004.05.206. [PubMed:15219862 ]