Hmdb loader
Identification
HMDB Protein ID HMDBP12097
Secondary Accession Numbers None
Name 2-acylglycerol O-acyltransferase 1
Synonyms
  1. Acyl-CoA:monoacylglycerol acyltransferase 1
  2. Diacylglycerol acyltransferase 2-like protein 1
  3. Monoacylglycerol O-acyltransferase 1
  4. MGAT1
Gene Name MOGAT1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Probably not involved in absorption of dietary fat in the small intestine.
Pathways
  • Glycerolipid metabolism
  • triacylglycerol biosynthesis
Reactions Not Available
GO Classification
Biological Process
glycerol metabolic process
diacylglycerol biosynthetic process
triglyceride biosynthetic process
lipid metabolic process
Cellular Component
endoplasmic reticulum membrane
endoplasmic reticulum
membrane
integral to membrane
Molecular Function
O-acyltransferase activity
2-acylglycerol O-acyltransferase activity
diacylglycerol O-acyltransferase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 335
Molecular Weight 38791.11
Theoretical pI 8.778
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 24-44;104-124;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q91ZV4
UniProtKB/Swiss-Prot Entry Name MOGT1_MOUSE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  3. Yen CL, Farese RV Jr: MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine. J Biol Chem. 2003 May 16;278(20):18532-7. Epub 2003 Mar 5. [PubMed:12621063 ]
  4. Cases S, Stone SJ, Zhou P, Yen E, Tow B, Lardizabal KD, Voelker T, Farese RV Jr: Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members. J Biol Chem. 2001 Oct 19;276(42):38870-6. Epub 2001 Jul 31. [PubMed:11481335 ]
  5. Yen CL, Brown CH 4th, Monetti M, Farese RV Jr: A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters. J Lipid Res. 2005 Nov;46(11):2388-97. Epub 2005 Aug 16. [PubMed:16106050 ]
  6. Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP: A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001. [PubMed:21183079 ]
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