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Identification
HMDB Protein ID HMDBP12104
Secondary Accession Numbers None
Name Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
Synonyms
  1. PIP5K1-alpha
  2. PtdIns(4)P-5-kinase 1 alpha
  3. 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha
  4. Phosphatidylinositol 4-phosphate 5-kinase type I alpha
  5. PIP5KIalpha
Gene Name PIP5K1A
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed:8955136, PubMed:21477596, PubMed:22942276). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (PubMed:19158393, PubMed:20660631). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis (By similarity). Can also use phosphatidylinositol (PtdIns) as substrate in vitro (PubMed:22942276). Together with PIP5K1C, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (By similarity). Promotes particle ingestion by activating the WAS GTPase-binding protein that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup (By similarity). Together with PIP5K1B, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity). Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, IP3 and DAG, that will mobilize internal calcium and drive keratinocyte differentiation (PubMed:19158393). Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes (By similarity). Together with PIP5K1C has a role during embryogenesis (By similarity). Independently of its catalytic activity, is required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of the small GTPase RAC1 to the plasma membrane (PubMed:20660631). Also functions in the nucleus where it acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs (PubMed:18288197).
Pathways
  • Choline metabolism in cancer
  • Endocytosis
  • Fc gamma R-mediated phagocytosis
  • Focal adhesion
  • Inositol phosphate metabolism
  • Phosphatidylinositol signaling system
  • Phospholipase D signaling pathway
  • Regulation of actin cytoskeleton
  • Yersinia infection
Reactions Not Available
GO Classification
Biological Process
signal transduction
keratinocyte differentiation
phosphatidylinositol biosynthetic process
cell chemotaxis
cell migration
activation of GTPase activity
phagocytosis
regulation of phosphatidylinositol 3-kinase cascade
glycerophospholipid metabolic process
focal adhesion assembly
ruffle assembly
actin cytoskeleton reorganization
protein localization to plasma membrane
phospholipid biosynthetic process
fibroblast migration
Cellular Component
cytosol
focal adhesion
plasma membrane
nucleus
nucleoplasm
nuclear speck
ruffle membrane
lamellipodium
Molecular Function
1-phosphatidylinositol-4-phosphate 5-kinase activity
ATP binding
kinase binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 562
Molecular Weight 62632.705
Theoretical pI 8.213
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q99755
UniProtKB/Swiss-Prot Entry Name PI51A_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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