Hmdb loader
Identification
HMDB Protein ID HMDBP12108
Secondary Accession Numbers None
Name Pancreatic lipase-related protein 2
Synonyms
  1. PL-RP2
  2. Cytotoxic T lymphocyte lipase
  3. Galactolipase
  4. Triacylglycerol lipase
Gene Name PNLIPRP2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Lipase that primarily hydrolyzes triglycerides and galactosylglycerides (PubMed:21382969, PubMed:9813028). In neonates, may play a major role in pancreatic digestion of dietary fats such as milk fat globules enriched in long-chain triglycerides (PubMed:9813028). Hydrolyzes short- medium- and long-chain fatty acyls in triglycerides without apparent positional specificity (PubMed:21382969). Can completely deacylates triacylglycerols (By similarity). When liver matures and bile salt synthesis increases, it likely functions mainly as a galactolipase and monoacylglycerol lipase. Hydrolyzes monogalactosyldiglycerols (MGDG) and digalactosyldiacylglycerols (DGDG) present in plant-based diet releasing long-chain polyunsaturated fatty acids (By similarity). Hydrolyzes medium- and long-chain fatty acyls in galactolipids (By similarity). May act together with LIPF to hydrolyze partially digested triglycerides (By similarity). Hydrolyzes long-chain monoglycerides with high efficiency (By similarity). In cytotoxic T cells, contributes to perforin-dependent cell lysis, but is unlikely to mediate direct cytotoxicity (PubMed:2302735, PubMed:9813028, PubMed:19451396). Has also low phospholipase activity, but its physiological relevance is not clear (By similarity).
Pathways
  • Fat digestion and absorption
  • Glycerolipid metabolism
  • Pancreatic secretion
  • triacylglycerol degradation
Reactions Not Available
GO Classification
Biological Process
response to bacterium
intestinal lipid catabolic process
phosphatidylcholine catabolic process
lipid catabolic process
phospholipid catabolic process
galactolipid catabolic process
cellular defense response
triglyceride catabolic process
Cellular Component
zymogen granule membrane
extracellular space
Molecular Function
lipase activity
phospholipase activity
triglyceride lipase activity
galactolipase activity
1-18:1-2-16:0-monogalactosyldiacylglycerol lipase activity
acylglycerol lipase activity
calcium ion binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 482
Molecular Weight 54016.195
Theoretical pI 6.645
Pfam Domain Function
Signals
  • 1-30;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P17892
UniProtKB/Swiss-Prot Entry Name LIPR2_MOUSE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  3. Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP: A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001. [PubMed:21183079 ]
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  5. Grusby MJ, Nabavi N, Wong H, Dick RF, Bluestone JA, Schotz MC, Glimcher LH: Cloning of an interleukin-4 inducible gene from cytotoxic T lymphocytes and its identification as a lipase. Cell. 1990 Feb 9;60(3):451-9. doi: 10.1016/0092-8674(90)90596-7. [PubMed:2302735 ]
  6. Lowe ME, Kaplan MH, Jackson-Grusby L, D'Agostino D, Grusby MJ: Decreased neonatal dietary fat absorption and T cell cytotoxicity in pancreatic lipase-related protein 2-deficient mice. J Biol Chem. 1998 Nov 20;273(47):31215-21. doi: 10.1074/jbc.273.47.31215. [PubMed:9813028 ]
  7. Alves BN, Leong J, Tamang DL, Elliott V, Edelnant J, Redelman D, Singer CA, Kuhn AR, Miller R, Lowe ME, Hudig D: Pancreatic lipase-related protein 2 (PLRP2) induction by IL-4 in cytotoxic T lymphocytes (CTLs) and reevaluation of the negative effects of its gene ablation on cytotoxicity. J Leukoc Biol. 2009 Sep;86(3):701-12. doi: 10.1189/jlb.1208766. Epub 2009 May 18. [PubMed:19451396 ]
  8. Xiao X, Ross LE, Miller RA, Lowe ME: Kinetic properties of mouse pancreatic lipase-related protein-2 suggest the mouse may not model human fat digestion. J Lipid Res. 2011 May;52(5):982-90. doi: 10.1194/jlr.M014290. Epub 2011 Mar 7. [PubMed:21382969 ]