| Identification |
|---|
| HMDB Protein ID
| HMDBP12113 |
| Secondary Accession Numbers
| None |
| Name
| Putative lipase ATG15 |
| Synonyms
|
- Autophagy-related protein 15
|
| Gene Name
| ATG15 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension (By similarity). |
| Pathways
|
- Autophagy - yeast
- Glycerolipid metabolism
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| macroautophagy |
| multivesicular body membrane disassembly |
| neutral lipid catabolic process |
| piecemeal microautophagy of the nucleus |
| Cellular Component |
| endoplasmic reticulum membrane |
| multivesicular body membrane |
| integral to membrane |
| Golgi membrane |
| Molecular Function |
| phospholipase activity |
| triglyceride lipase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 522 |
| Molecular Weight
| 57209.675 |
| Theoretical pI
| 5.608 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P0CO60 |
| UniProtKB/Swiss-Prot Entry Name
| ATG15_CRYNJ |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Loftus BJ, Fung E, Roncaglia P, Rowley D, Amedeo P, Bruno D, Vamathevan J, Miranda M, Anderson IJ, Fraser JA, Allen JE, Bosdet IE, Brent MR, Chiu R, Doering TL, Donlin MJ, D'Souza CA, Fox DS, Grinberg V, Fu J, Fukushima M, Haas BJ, Huang JC, Janbon G, Jones SJ, Koo HL, Krzywinski MI, Kwon-Chung JK, Lengeler KB, Maiti R, Marra MA, Marra RE, Mathewson CA, Mitchell TG, Pertea M, Riggs FR, Salzberg SL, Schein JE, Shvartsbeyn A, Shin H, Shumway M, Specht CA, Suh BB, Tenney A, Utterback TR, Wickes BL, Wortman JR, Wye NH, Kronstad JW, Lodge JK, Heitman J, Davis RW, Fraser CM, Hyman RW: The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans. Science. 2005 Feb 25;307(5713):1321-4. doi: 10.1126/science.1103773. Epub 2005 Jan 13. [PubMed:15653466 ]
|
