Hmdb loader
HMDB Protein ID HMDBP12117
Secondary Accession Numbers None
Name Fat storage-inducing transmembrane protein 1
  1. Fat-inducing protein 1
Gene Name FITM1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Plays an important role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (PubMed:18160536) (By similarity). Directly binds to diacylglycerol (DAGs) and triacylglycerol (By similarity).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
lipid storage
positive regulation of sequestering of triglyceride
lipid droplet formation
lipid droplet organization
phospholipid biosynthetic process
Cellular Component
endoplasmic reticulum membrane
integral to endoplasmic reticulum membrane
Molecular Function
diacylglycerol binding
triglyceride binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 292
Molecular Weight 32206.615
Theoretical pI 9.786
Pfam Domain Function Not Available
Signals Not Available
Transmembrane Regions
  • 19-39;55-75;95-115;142-162;188-208;221-241;250-270;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID A5D6W6
UniProtKB/Swiss-Prot Entry Name FITM1_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Kadereit B, Kumar P, Wang WJ, Miranda D, Snapp EL, Severina N, Torregroza I, Evans T, Silver DL: Evolutionarily conserved gene family important for fat storage. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):94-9. doi: 10.1073/pnas.0708579105. Epub 2007 Dec 26. [PubMed:18160536 ]