| Identification |
|---|
| HMDB Protein ID
| HMDBP12127 |
| Secondary Accession Numbers
| None |
| Name
| Arylacetamide deacetylase |
| Synonyms
|
Not Available
|
| Gene Name
| AADAC |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly (By similarity). Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| positive regulation of triglyceride catabolic process |
| lipid metabolic process |
| Cellular Component |
| endoplasmic reticulum membrane |
| integral to membrane |
| Molecular Function |
| deacetylase activity |
| serine hydrolase activity |
| triglyceride lipase activity |
| hydrolase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 398 |
| Molecular Weight
| 45692.435 |
| Theoretical pI
| 7.689 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9QZH8 |
| UniProtKB/Swiss-Prot Entry Name
| AAAD_RAT |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Trickett JI, Patel DD, Knight BL, Saggerson ED, Gibbons GF, Pease RJ: Characterization of the rodent genes for arylacetamide deacetylase, a putative microsomal lipase, and evidence for transcriptional regulation. J Biol Chem. 2001 Oct 26;276(43):39522-32. doi: 10.1074/jbc.M101764200. Epub 2001 Jul 31. [PubMed:11481320 ]
- Kobayashi Y, Fukami T, Nakajima A, Watanabe A, Nakajima M, Yokoi T: Species differences in tissue distribution and enzyme activities of arylacetamide deacetylase in human, rat, and mouse. Drug Metab Dispos. 2012 Apr;40(4):671-9. doi: 10.1124/dmd.111.043067. Epub 2011 Dec 29. [PubMed:22207054 ]
|
