Hmdb loader
Identification
HMDB Protein ID HMDBP12131
Secondary Accession Numbers None
Name Monoacylglycerol lipase ABHD2
Synonyms
  1. 2-arachidonoylglycerol hydrolase
  2. Abhydrolase domain-containing protein 2
  3. Acetylesterase
  4. Lung alpha/beta hydrolase 2
  5. Progesterone-sensitive lipase
  6. Protein PHPS1-2
Gene Name ABHD2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane (PubMed:26989199). Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA) (PubMed:26989199). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester (PubMed:27247428). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (PubMed:26989199). May also play a role in smooth muscle cells migration (By similarity).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
sperm capacitation
response to progesterone stimulus
response to wounding
medium-chain fatty acid biosynthetic process
acrosome reaction
acylglycerol catabolic process
steroid hormone mediated signaling pathway
negative regulation of cell migration
cellular lipid metabolic process
medium-chain fatty acid catabolic process
Cellular Component
sperm flagellum
sperm plasma membrane
acrosomal vesicle
integral to membrane
Molecular Function
triglyceride lipase activity
hormone-sensitive lipase activity
acetylesterase activity
short-chain carboxylesterase activity
steroid hormone receptor activity
acylglycerol lipase activity
hormone binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 425
Molecular Weight 48314.51
Theoretical pI 6.696
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 10-30;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P08910
UniProtKB/Swiss-Prot Entry Name ABHD2_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Rapiejko PJ, George ST, Malbon CC: Primary structure of a human protein which bears structural similarities to members of the rhodopsin/beta-adrenergic receptor family. Nucleic Acids Res. 1988 Sep 12;16(17):8721. doi: 10.1093/nar/16.17.8721. [PubMed:2843827 ]
  3. M NK, V B S C T, G K V, B CS, Guntupalli S, J S B: Molecular characterization of human ABHD2 as TAG lipase and ester hydrolase. Biosci Rep. 2016 Jul 15;36(4). pii: BSR20160033. doi: 10.1042/BSR20160033. Print 2016 Aug. [PubMed:27247428 ]
  4. Miller MR, Mannowetz N, Iavarone AT, Safavi R, Gracheva EO, Smith JF, Hill RZ, Bautista DM, Kirichok Y, Lishko PV: Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone. Science. 2016 Apr 29;352(6285):555-9. doi: 10.1126/science.aad6887. Epub 2016 Mar 17. [PubMed:26989199 ]