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Showing Protein Fibroblast growth factor receptor 1-A (HMDBP12141)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP12141
Secondary Accession Numbers None
Name Fibroblast growth factor receptor 1-A
Synonyms
  1. FGFR-1-A
  2. bFGF-R-1-A
  3. Basic fibroblast growth factor receptor 1-A
Gene Name FGFR1A
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by ubiquitination, internalization and degradation (By similarity).
Pathways
  • Adherens junction
  • Calcium signaling pathway
  • MAPK signaling pathway
  • Regulation of actin cytoskeleton
Reactions Not Available
GO Classification
Biological Process
multicellular organismal development
positive regulation of cell proliferation
positive regulation of kinase activity
positive regulation of phospholipase C activity
liver development
response to ethanol
peptidyl-tyrosine phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
cardiac muscle tissue development
anatomical structure homeostasis
fin regeneration
negative regulation of endodermal cell fate specification
olfactory nerve formation
olfactory placode morphogenesis
positive regulation of cell differentiation
post-anal tail morphogenesis
posterior lateral line development
skin morphogenesis
dorsal/ventral pattern formation
positive regulation of MAP kinase activity
fibroblast growth factor receptor signaling pathway
Cellular Component
cytosol
receptor complex
plasma membrane
nucleus
cytoplasmic vesicle
integral to plasma membrane
Molecular Function
transmembrane receptor protein tyrosine kinase activity
ATP binding
heparin binding
fibroblast growth factor binding
fibroblast growth factor-activated receptor activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 810
Molecular Weight 91040.585
Theoretical pI 6.821
Pfam Domain Function
Signals
  • 1-26;
Transmembrane Regions
  • 364-384;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q90Z00
UniProtKB/Swiss-Prot Entry Name FGR1A_DANRE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Howe K, Clark MD, Torroja CF, Torrance J, Berthelot C, Muffato M, Collins JE, Humphray S, McLaren K, Matthews L, McLaren S, Sealy I, Caccamo M, Churcher C, Scott C, Barrett JC, Koch R, Rauch GJ, White S, Chow W, Kilian B, Quintais LT, Guerra-Assuncao JA, Zhou Y, Gu Y, Yen J, Vogel JH, Eyre T, Redmond S, Banerjee R, Chi J, Fu B, Langley E, Maguire SF, Laird GK, Lloyd D, Kenyon E, Donaldson S, Sehra H, Almeida-King J, Loveland J, Trevanion S, Jones M, Quail M, Willey D, Hunt A, Burton J, Sims S, McLay K, Plumb B, Davis J, Clee C, Oliver K, Clark R, Riddle C, Elliot D, Threadgold G, Harden G, Ware D, Begum S, Mortimore B, Kerry G, Heath P, Phillimore B, Tracey A, Corby N, Dunn M, Johnson C, Wood J, Clark S, Pelan S, Griffiths G, Smith M, Glithero R, Howden P, Barker N, Lloyd C, Stevens C, Harley J, Holt K, Panagiotidis G, Lovell J, Beasley H, Henderson C, Gordon D, Auger K, Wright D, Collins J, Raisen C, Dyer L, Leung K, Robertson L, Ambridge K, Leongamornlert D, McGuire S, Gilderthorp R, Griffiths C, Manthravadi D, Nichol S, Barker G, Whitehead S, Kay M, Brown J, Murnane C, Gray E, Humphries M, Sycamore N, Barker D, Saunders D, Wallis J, Babbage A, Hammond S, Mashreghi-Mohammadi M, Barr L, Martin S, Wray P, Ellington A, Matthews N, Ellwood M, Woodmansey R, Clark G, Cooper J, Tromans A, Grafham D, Skuce C, Pandian R, Andrews R, Harrison E, Kimberley A, Garnett J, Fosker N, Hall R, Garner P, Kelly D, Bird C, Palmer S, Gehring I, Berger A, Dooley CM, Ersan-Urun Z, Eser C, Geiger H, Geisler M, Karotki L, Kirn A, Konantz J, Konantz M, Oberlander M, Rudolph-Geiger S, Teucke M, Lanz C, Raddatz G, Osoegawa K, Zhu B, Rapp A, Widaa S, Langford C, Yang F, Schuster SC, Carter NP, Harrow J, Ning Z, Herrero J, Searle SM, Enright A, Geisler R, Plasterk RH, Lee C, Westerfield M, de Jong PJ, Zon LI, Postlethwait JH, Nusslein-Volhard C, Hubbard TJ, Roest Crollius H, Rogers J, Stemple DL: The zebrafish reference genome sequence and its relationship to the human genome. Nature. 2013 Apr 25;496(7446):498-503. doi: 10.1038/nature12111. Epub 2013 Apr 17. [PubMed:23594743 ]
  2. Scholpp S, Groth C, Lohs C, Lardelli M, Brand M: Zebrafish fgfr1 is a member of the fgf8 synexpression group and is required for fgf8 signalling at the midbrain-hindbrain boundary. Dev Genes Evol. 2004 Jun;214(6):285-95. doi: 10.1007/s00427-004-0409-1. Epub 2004 May 25. [PubMed:15221377 ]
  3. Bushell KM, Sollner C, Schuster-Boeckler B, Bateman A, Wright GJ: Large-scale screening for novel low-affinity extracellular protein interactions. Genome Res. 2008 Apr;18(4):622-30. doi: 10.1101/gr.7187808. Epub 2008 Feb 22. [PubMed:18296487 ]
  4. Hirate Y, Okamoto H: Canopy1, a novel regulator of FGF signaling around the midbrain-hindbrain boundary in zebrafish. Curr Biol. 2006 Feb 21;16(4):421-7. doi: 10.1016/j.cub.2006.01.055. [PubMed:16488878 ]