Hmdb loader
Identification
HMDB Protein ID HMDBP12146
Secondary Accession Numbers None
Name Lipase 1
Synonyms
  1. GCL I
  2. Lipase I
Gene Name LIP1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Hydrolyzes all ester bonds in triglyceride and displays a high affinity for triolein. For unsaturated substrates having long fatty acyl chains (C18:2 cis-9, cis-12 and C18:3 cis-9, cis-12, cis-15) GCL I shows higher specific activity than GCL II, whereas GCL II shows higher specific activity against saturated substrates having short fatty acid chains (C8, C10, C12 and C14).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
lipid catabolic process
Cellular Component
extracellular region
Molecular Function
triglyceride lipase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 61198.54
Theoretical pI Not Available
Pfam Domain Function
Signals
  • 1-19;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P17573
UniProtKB/Swiss-Prot Entry Name LIP1_GEOCN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Shimada Y, Sugihara A, Tominaga Y, Iizumi T, Tsunasawa S: cDNA molecular cloning of Geotrichum candidum lipase. J Biochem. 1989 Sep;106(3):383-8. doi: 10.1093/oxfordjournals.jbchem.a122862. [PubMed:2481674 ]
  2. Bertolini MC, Laramee L, Thomas DY, Cygler M, Schrag JD, Vernet T: Polymorphism in the lipase genes of Geotrichum candidum strains. Eur J Biochem. 1994 Jan 15;219(1-2):119-25. doi: 10.1111/j.1432-1033.1994.tb19921.x. [PubMed:8306978 ]
  3. Nagao T, Shimada Y, Sugihara A, Tominaga Y: Cloning and sequencing of two chromosomal lipase genes from Geotrichum candidum. J Biochem. 1993 Jun;113(6):776-80. doi: 10.1093/oxfordjournals.jbchem.a124117. [PubMed:8370674 ]
  4. Slabas AR, Windust J, Sidebottom CM: Does sequence similarity of human choline esterase, Torpedo acetylcholine esterase and Geotrichum candidum lipase reveal the active site serine residue? Biochem J. 1990 Jul 1;269(1):279-80. doi: 10.1042/bj2690279. [PubMed:2115773 ]
  5. Bertolini MC, Schrag JD, Cygler M, Ziomek E, Thomas DY, Vernet T: Expression and characterization of Geotrichum candidum lipase I gene. Comparison of specificity profile with lipase II. Eur J Biochem. 1995 Mar 15;228(3):863-9. [PubMed:7737187 ]