Hmdb loader
Identification
HMDB Protein ID HMDBP12165
Secondary Accession Numbers None
Name ABC multidrug transporter MDR1
Synonyms
  1. Multidrug resistance protein 1
Gene Name MDR1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Pleiotropic ABC efflux transporter that may be involved in the modulation susceptibility to a wide range of unrelated cytotoxic compounds, including ethidium bromide, ketoconazole, cycloheximide, fluconazole, griseofulvin, imazalil and itraconazole.
Pathways Not Available
Reactions Not Available
GO Classification
Cellular Component
plasma membrane
integral to membrane
Molecular Function
ATP binding
ATPase-coupled transmembrane transporter activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 174820.68
Theoretical pI Not Available
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 543-563;571-591;636-656;661-681;691-711;798-818;1231-1251;1257-1277;1305-1325;1345-1365;1372-1392;1498-1518;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID A0A059J0G5
UniProtKB/Swiss-Prot Entry Name MDR1_TRIIM
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Persinoti GF, Martinez DA, Li W, Dogen A, Billmyre RB, Averette A, Goldberg JM, Shea T, Young S, Zeng Q, Oliver BG, Barton R, Metin B, Hilmioglu-Polat S, Ilkit M, Graser Y, Martinez-Rossi NM, White TC, Heitman J, Cuomo CA: Whole-Genome Analysis Illustrates Global Clonal Population Structure of the Ubiquitous Dermatophyte Pathogen Trichophyton rubrum. Genetics. 2018 Apr;208(4):1657-1669. doi: 10.1534/genetics.117.300573. Epub 2018 Feb 21. [PubMed:29467168 ]
  2. Cervelatti EP, Fachin AL, Ferreira-Nozawa MS, Martinez-Rossi NM: Molecular cloning and characterization of a novel ABC transporter gene in the human pathogen Trichophyton rubrum. Med Mycol. 2006 Mar;44(2):141-7. doi: 10.1080/13693780500220449. [PubMed:16519017 ]
  3. Martins MP, Franceschini ACC, Jacob TR, Rossi A, Martinez-Rossi NM: Compensatory expression of multidrug-resistance genes encoding ABC transporters in dermatophytes. J Med Microbiol. 2016 Jul;65(7):605-610. doi: 10.1099/jmm.0.000268. Epub 2016 Apr 26. [PubMed:27121717 ]