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Showing Protein Glutathione S-transferase LANCL1 (HMDBP12167)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP12167
Secondary Accession Numbers None
Name Glutathione S-transferase LANCL1
Synonyms
  1. 40 kDa erythrocyte membrane protein
  2. LanC-like protein 1
  3. p40
Gene Name LANCL1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Functions as glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism (By similarity). May play a role in EPS8 signaling. Binds glutathione (PubMed:19528316).
Pathways
  • Glutathione metabolism
Reactions Not Available
GO Classification
Biological Process
regulation of neuron apoptotic process
G-protein coupled receptor signaling pathway
carbohydrate metabolic process
regulation of oxidative stress-induced neuron death
Cellular Component
cytoplasm
plasma membrane
integral to plasma membrane
Molecular Function
glutathione binding
glutathione transferase activity
SH3 domain binding
zinc ion binding
G protein-coupled receptor activity
low-density lipoprotein particle receptor binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 399
Molecular Weight 45282.71
Theoretical pI 7.754
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O43813
UniProtKB/Swiss-Prot Entry Name LANC1_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Mayer H, Salzer U, Breuss J, Ziegler S, Marchler-Bauer A, Prohaska R: Isolation, molecular characterization, and tissue-specific expression of a novel putative G protein-coupled receptor. Biochim Biophys Acta. 1998 Feb 11;1395(3):301-8. doi: 10.1016/s0167-4781(97)00178-4. [PubMed:9512664 ]
  3. Mayer H, Bauer H, Prohaska R: Organization and chromosomal localization of the human and mouse genes coding for LanC-like protein 1 (LANCL1). Cytogenet Cell Genet. 2001;93(1-2):100-4. doi: 10.1159/000056958. [PubMed:11474189 ]
  4. Bauer H, Mayer H, Marchler-Bauer A, Salzer U, Prohaska R: Characterization of p40/GPR69A as a peripheral membrane protein related to the lantibiotic synthetase component C. Biochem Biophys Res Commun. 2000 Aug 18;275(1):69-74. doi: 10.1006/bbrc.2000.3260. [PubMed:10944443 ]
  5. Blisnick T, Vincensini L, Barale JC, Namane A, Braun Breton C: LANCL1, an erythrocyte protein recruited to the Maurer's clefts during Plasmodium falciparum development. Mol Biochem Parasitol. 2005 May;141(1):39-47. doi: 10.1016/j.molbiopara.2005.01.013. [PubMed:15811525 ]