| Identification |
|---|
| HMDB Protein ID
| HMDBP12181 |
| Secondary Accession Numbers
| None |
| Name
| Cytochrome P450 2D6 |
| Synonyms
|
- CYPIID6
- Cholesterol 25-hydroxylase
- Cytochrome P450-DB1
- Debrisoquine 4-hydroxylase
|
| Gene Name
| CYP2D6 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling. Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis. Catalyzes the oxidative transformations of all-trans retinol to all-trans retinal, a precursor for the active form all-trans-retinoic acid. Also involved in the oxidative metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants. |
| Pathways
|
- cholesterol metabolism
- Drug metabolism - cytochrome P450
- Endocrine resistance
- fatty acid metabolism
- Metabolism of xenobiotics by cytochrome P450
- retinol metabolism
- Serotonergic synapse
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| retinol metabolic process |
| cholesterol metabolic process |
| exogenous drug catabolic process |
| xenobiotic metabolic process |
| organic acid metabolic process |
| arachidonic acid metabolic process |
| Cellular Component |
| endoplasmic reticulum membrane |
| cytoplasm |
| intracellular membrane-bounded organelle |
| Molecular Function |
| anandamide 11,12 epoxidase activity |
| anandamide 14,15 epoxidase activity |
| anandamide 8,9 epoxidase activity |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| iron ion binding |
| steroid hydroxylase activity |
| heme binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 497 |
| Molecular Weight
| 55861.1 |
| Theoretical pI
| 7.853 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q2XNC8 |
| UniProtKB/Swiss-Prot Entry Name
| CP2D6_PANTR |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
