Hmdb loader
Identification
HMDB Protein ID HMDBP12184
Secondary Accession Numbers None
Name mRNA decay activator protein ZFP36L2
Synonyms
  1. Butyrate response factor 2
  2. EGF-response factor 2
  3. TPA-induced sequence 11d
  4. Zinc finger protein 36, C3H1 type-like 2
  5. ERF-2
  6. ZFP36-like 2
Gene Name ZFP36L2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:25106868, PubMed:14981510). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:20506496, PubMed:25106868, PubMed:14981510). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA.
Pathways
  • Cellular senescence
Reactions Not Available
GO Classification
Biological Process
3'-UTR-mediated mRNA destabilization
definitive hemopoiesis
ERK1 and ERK2 cascade
negative regulation of mitotic cell cycle phase transition
negative regulation of stem cell differentiation
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
regulation of mRNA stability
somatic stem cell division
cellular response to fibroblast growth factor stimulus
somatic stem cell maintenance
T cell differentiation in thymus
negative regulation of fat cell differentiation
response to wounding
cellular response to tumor necrosis factor
hemopoiesis
regulation of B cell differentiation
cellular response to epidermal growth factor stimulus
cellular response to granulocyte macrophage colony-stimulating factor stimulus
cellular response to glucocorticoid stimulus
cellular response to transforming growth factor beta stimulus
mRNA catabolic process
Cellular Component
cytoplasm
nucleus
Molecular Function
mRNA 3'-UTR AU-rich region binding
metal ion binding
RNA binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 494
Molecular Weight 51062.055
Theoretical pI 8.168
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P47974
UniProtKB/Swiss-Prot Entry Name TISD_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  3. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  4. Ino T, Yasui H, Hirano M, Kurosawa Y: Identification of a member of the TIS11 early response gene family at the insertion point of a DNA fragment containing a gene for the T-cell receptor beta chain in an acute T-cell leukemia. Oncogene. 1995 Dec 21;11(12):2705-10. [PubMed:8545129 ]
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  6. Maclean KN, McKay IA, Bustin SA: Differential effects of sodium butyrate on the transcription of the human TIS11 family of early-response genes in colorectal cancer cells. Br J Biomed Sci. 1998 Sep;55(3):184-91. [PubMed:10367403 ]