Hmdb loader
Identification
HMDB Protein ID HMDBP12185
Secondary Accession Numbers None
Name Adenosine deaminase-like protein
Synonyms
  1. Adenosine deaminase-like protein isoform 1
  2. N6-mAMP deaminase
  3. N6-methyl-AMP aminohydrolase
  4. HsMAPDA
Gene Name ADAL
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine (PubMed:21755941, PubMed:29884623). Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A) (PubMed:21755941, PubMed:29884623). Catalyzes the removal of different alkyl groups not only from N6-substituted purine or 2-aminopurine nucleoside monophosphates but also from O6-substituted compounds in vitro (PubMed:21755941).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
nucleotide metabolic process
drug metabolic process
purine-containing compound salvage
adenosine catabolic process
inosine biosynthetic process
Cellular Component
cytosol
Molecular Function
N6-mAMP deaminase activity
metal ion binding
adenosine deaminase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 355
Molecular Weight 40263.61
Theoretical pI 6.318
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q6DHV7
UniProtKB/Swiss-Prot Entry Name ADAL_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  3. Zody MC, Garber M, Sharpe T, Young SK, Rowen L, O'Neill K, Whittaker CA, Kamal M, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Kodira CD, Madan A, Qin S, Yang X, Abbasi N, Abouelleil A, Arachchi HM, Baradarani L, Birditt B, Bloom S, Bloom T, Borowsky ML, Burke J, Butler J, Cook A, DeArellano K, DeCaprio D, Dorris L 3rd, Dors M, Eichler EE, Engels R, Fahey J, Fleetwood P, Friedman C, Gearin G, Hall JL, Hensley G, Johnson E, Jones C, Kamat A, Kaur A, Locke DP, Madan A, Munson G, Jaffe DB, Lui A, Macdonald P, Mauceli E, Naylor JW, Nesbitt R, Nicol R, O'Leary SB, Ratcliffe A, Rounsley S, She X, Sneddon KM, Stewart S, Sougnez C, Stone SM, Topham K, Vincent D, Wang S, Zimmer AR, Birren BW, Hood L, Lander ES, Nusbaum C: Analysis of the DNA sequence and duplication history of human chromosome 15. Nature. 2006 Mar 30;440(7084):671-5. [PubMed:16572171 ]
  4. Murakami E, Bao H, Mosley RT, Du J, Sofia MJ, Furman PA: Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates. J Med Chem. 2011 Aug 25;54(16):5902-14. doi: 10.1021/jm200650j. Epub 2011 Jul 22. [PubMed:21755941 ]
  5. Chen M, Urs MJ, Sanchez-Gonzalez I, Olayioye MA, Herde M, Witte CP: m(6)A RNA Degradation Products Are Catabolized by an Evolutionarily Conserved N(6)-Methyl-AMP Deaminase in Plant and Mammalian Cells. Plant Cell. 2018 Jul;30(7):1511-1522. doi: 10.1105/tpc.18.00236. Epub 2018 Jun 8. [PubMed:29884623 ]