| Identification |
|---|
| HMDB Protein ID
| HMDBP12189 |
| Secondary Accession Numbers
| None |
| Name
| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase |
| Synonyms
|
- MECDP-synthase
- MECPP-synthase
- MECPS
|
| Gene Name
| ISPF |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). |
| Pathways
|
- Biosynthesis of secondary metabolites
- isopentenyl diphosphate biosynthesis via DXP pathway
- Terpenoid backbone biosynthesis
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
| terpenoid biosynthetic process |
| Molecular Function |
| metal ion binding |
| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 173 |
| Molecular Weight
| 19068.8 |
| Theoretical pI
| 7.099 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q2GHV0 |
| UniProtKB/Swiss-Prot Entry Name
| ISPF_EHRCR |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Dunning Hotopp JC, Lin M, Madupu R, Crabtree J, Angiuoli SV, Eisen JA, Seshadri R, Ren Q, Wu M, Utterback TR, Smith S, Lewis M, Khouri H, Zhang C, Niu H, Lin Q, Ohashi N, Zhi N, Nelson W, Brinkac LM, Dodson RJ, Rosovitz MJ, Sundaram J, Daugherty SC, Davidsen T, Durkin AS, Gwinn M, Haft DH, Selengut JD, Sullivan SA, Zafar N, Zhou L, Benahmed F, Forberger H, Halpin R, Mulligan S, Robinson J, White O, Rikihisa Y, Tettelin H: Comparative genomics of emerging human ehrlichiosis agents. PLoS Genet. 2006 Feb;2(2):e21. doi: 10.1371/journal.pgen.0020021. Epub 2006 Feb 17. [PubMed:16482227 ]
|
