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Identification
HMDB Protein ID HMDBP12197
Secondary Accession Numbers None
Name 1-deoxy-D-xylulose 5-phosphate reductoisomerase
Synonyms
  1. DXP reductoisomerase
  2. 1-deoxyxylulose-5-phosphate reductoisomerase
  3. 2-C-methyl-D-erythritol 4-phosphate synthase
Gene Name DXR
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
Pathways
  • Biosynthesis of secondary metabolites
  • isopentenyl diphosphate biosynthesis via DXP pathway
  • Terpenoid backbone biosynthesis
Reactions Not Available
GO Classification
Biological Process
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
terpenoid biosynthetic process
Molecular Function
metal ion binding
1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NADPH binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 380
Molecular Weight 41973.185
Theoretical pI 5.272
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID C4Z5K1
UniProtKB/Swiss-Prot Entry Name DXR_LACE2
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Mahowald MA, Rey FE, Seedorf H, Turnbaugh PJ, Fulton RS, Wollam A, Shah N, Wang C, Magrini V, Wilson RK, Cantarel BL, Coutinho PM, Henrissat B, Crock LW, Russell A, Verberkmoes NC, Hettich RL, Gordon JI: Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5859-64. doi: 10.1073/pnas.0901529106. Epub 2009 Mar 24. [PubMed:19321416 ]