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Showing Protein 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic (HMDBP12205)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP12205
Secondary Accession Numbers None
Name 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic
Synonyms
  1. 1-deoxyxylulose-5-phosphate reductoisomerase
  2. DOXP reductoisomerase
  3. DXP reductoisomerase
Gene Name DXR
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
Pathways
  • isopentenyl diphosphate biosynthesis via DXP pathway
Reactions Not Available
GO Classification
Biological Process
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
Cellular Component
apicoplast
Molecular Function
metal ion binding
1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NADPH binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 55756.205
Theoretical pI Not Available
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O96693
UniProtKB/Swiss-Prot Entry Name DXR_PLAFX
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Jomaa H, Wiesner J, Sanderbrand S, Altincicek B, Weidemeyer C, Hintz M, Turbachova I, Eberl M, Zeidler J, Lichtenthaler HK, Soldati D, Beck E: Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science. 1999 Sep 3;285(5433):1573-6. doi: 10.1126/science.285.5433.1573. [PubMed:10477522 ]