| Identification |
|---|
| HMDB Protein ID
| HMDBP12206 |
| Secondary Accession Numbers
| None |
| Name
| 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic |
| Synonyms
|
- 1-deoxyxylulose-5-phosphate reductoisomerase
- DOXP reductoisomerase
- DXP reductoisomerase
|
| Gene Name
| DXR |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP). |
| Pathways
|
- Biosynthesis of secondary metabolites
- isopentenyl diphosphate biosynthesis via DXP pathway
- Terpenoid backbone biosynthesis
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process |
| Cellular Component |
| apicoplast |
| Molecular Function |
| manganese ion binding |
| 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity |
| NADPH binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 488 |
| Molecular Weight
| 55756.205 |
| Theoretical pI
| 8.612 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q8IKG4 |
| UniProtKB/Swiss-Prot Entry Name
| DXR_PLAF7 |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Gardner MJ, Hall N, Fung E, White O, Berriman M, Hyman RW, Carlton JM, Pain A, Nelson KE, Bowman S, Paulsen IT, James K, Eisen JA, Rutherford K, Salzberg SL, Craig A, Kyes S, Chan MS, Nene V, Shallom SJ, Suh B, Peterson J, Angiuoli S, Pertea M, Allen J, Selengut J, Haft D, Mather MW, Vaidya AB, Martin DM, Fairlamb AH, Fraunholz MJ, Roos DS, Ralph SA, McFadden GI, Cummings LM, Subramanian GM, Mungall C, Venter JC, Carucci DJ, Hoffman SL, Newbold C, Davis RW, Fraser CM, Barrell B: Genome sequence of the human malaria parasite Plasmodium falciparum. Nature. 2002 Oct 3;419(6906):498-511. doi: 10.1038/nature01097. [PubMed:12368864 ]
|
