Hmdb loader
Identification
HMDB Protein ID HMDBP12214
Secondary Accession Numbers None
Name 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)
Synonyms
  1. 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase
Gene Name ISPG
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
Pathways
  • Biosynthesis of secondary metabolites
  • isopentenyl diphosphate biosynthesis via DXP pathway
  • Terpenoid backbone biosynthesis
Reactions Not Available
GO Classification
Biological Process
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
terpenoid biosynthetic process
Molecular Function
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity
4 iron, 4 sulfur cluster binding
iron ion binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 372
Molecular Weight 40683.225
Theoretical pI 6.219
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID A1AE53
UniProtKB/Swiss-Prot Entry Name ISPG_ECOK1
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Johnson TJ, Kariyawasam S, Wannemuehler Y, Mangiamele P, Johnson SJ, Doetkott C, Skyberg JA, Lynne AM, Johnson JR, Nolan LK: The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes. J Bacteriol. 2007 Apr;189(8):3228-36. doi: 10.1128/JB.01726-06. Epub 2007 Feb 9. [PubMed:17293413 ]