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Showing Protein 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (HMDBP12255)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP12255
Secondary Accession Numbers None
Name 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Synonyms
  1. MECDP-synthase
  2. MECPS
Gene Name ISPF
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Converts 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate into 2C-methyl-D-erythritol 2,4-cyclodiphosphate and CMP.
Pathways
  • Biosynthesis of secondary metabolites
  • isopentenyl diphosphate biosynthesis via DXP pathway
  • Terpenoid backbone biosynthesis
Reactions Not Available
GO Classification
Biological Process
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
terpenoid biosynthetic process
Cellular Component
apicoplast
Molecular Function
metal ion binding
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 240
Molecular Weight 27160.405
Theoretical pI 9.421
Pfam Domain Function
Signals
  • 1-24;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P62368
UniProtKB/Swiss-Prot Entry Name ISPF_PLAF7
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Gardner MJ, Hall N, Fung E, White O, Berriman M, Hyman RW, Carlton JM, Pain A, Nelson KE, Bowman S, Paulsen IT, James K, Eisen JA, Rutherford K, Salzberg SL, Craig A, Kyes S, Chan MS, Nene V, Shallom SJ, Suh B, Peterson J, Angiuoli S, Pertea M, Allen J, Selengut J, Haft D, Mather MW, Vaidya AB, Martin DM, Fairlamb AH, Fraunholz MJ, Roos DS, Ralph SA, McFadden GI, Cummings LM, Subramanian GM, Mungall C, Venter JC, Carucci DJ, Hoffman SL, Newbold C, Davis RW, Fraser CM, Barrell B: Genome sequence of the human malaria parasite Plasmodium falciparum. Nature. 2002 Oct 3;419(6906):498-511. doi: 10.1038/nature01097. [PubMed:12368864 ]
  2. Gardner MJ, Tettelin H, Carucci DJ, Cummings LM, Aravind L, Koonin EV, Shallom S, Mason T, Yu K, Fujii C, Pederson J, Shen K, Jing J, Aston C, Lai Z, Schwartz DC, Pertea M, Salzberg S, Zhou L, Sutton GG, Clayton R, White O, Smith HO, Fraser CM, Adams MD, Venter JC, Hoffman SL: Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Science. 1998 Nov 6;282(5391):1126-32. doi: 10.1126/science.282.5391.1126. [PubMed:9804551 ]
  3. O'Rourke PE, Kalinowska-Tluscik J, Fyfe PK, Dawson A, Hunter WN: Crystal structures of IspF from Plasmodium falciparum and Burkholderia cenocepacia: comparisons inform antimicrobial drug target assessment. BMC Struct Biol. 2014 Jan 10;14:1. doi: 10.1186/1472-6807-14-1. [PubMed:24410837 ]