| Identification |
|---|
| HMDB Protein ID
| HMDBP12257 |
| Secondary Accession Numbers
| None |
| Name
| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase |
| Synonyms
|
- MECDP-synthase
- MECPP-synthase
- MECPS
|
| Gene Name
| ISPF |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). |
| Pathways
|
- Biosynthesis of secondary metabolites
- isopentenyl diphosphate biosynthesis via DXP pathway
- Terpenoid backbone biosynthesis
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
| terpenoid biosynthetic process |
| Molecular Function |
| metal ion binding |
| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 168 |
| Molecular Weight
| 16828.925 |
| Theoretical pI
| 5.403 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q6AAV7 |
| UniProtKB/Swiss-Prot Entry Name
| ISPF_CUTAK |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Bruggemann H, Henne A, Hoster F, Liesegang H, Wiezer A, Strittmatter A, Hujer S, Durre P, Gottschalk G: The complete genome sequence of Propionibacterium acnes, a commensal of human skin. Science. 2004 Jul 30;305(5684):671-3. doi: 10.1126/science.1100330. [PubMed:15286373 ]
|
