| Identification |
|---|
| HMDB Protein ID
| HMDBP12262 |
| Secondary Accession Numbers
| None |
| Name
| 1-deoxy-D-xylulose 5-phosphate reductoisomerase |
| Synonyms
|
- DXP reductoisomerase
- 1-deoxyxylulose-5-phosphate reductoisomerase
- 2-C-methyl-D-erythritol 4-phosphate synthase
|
| Gene Name
| DXR |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP). |
| Pathways
|
- Biosynthesis of secondary metabolites
- isopentenyl diphosphate biosynthesis via DXP pathway
- Terpenoid backbone biosynthesis
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
| terpenoid biosynthetic process |
| Molecular Function |
| metal ion binding |
| 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity |
| NADPH binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 389 |
| Molecular Weight
| 42738.32 |
| Theoretical pI
| 8.09 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q5GTA4 |
| UniProtKB/Swiss-Prot Entry Name
| DXR_WOLTR |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Foster J, Ganatra M, Kamal I, Ware J, Makarova K, Ivanova N, Bhattacharyya A, Kapatral V, Kumar S, Posfai J, Vincze T, Ingram J, Moran L, Lapidus A, Omelchenko M, Kyrpides N, Ghedin E, Wang S, Goltsman E, Joukov V, Ostrovskaya O, Tsukerman K, Mazur M, Comb D, Koonin E, Slatko B: The Wolbachia genome of Brugia malayi: endosymbiont evolution within a human pathogenic nematode. PLoS Biol. 2005 Apr;3(4):e121. doi: 10.1371/journal.pbio.0030121. Epub 2005 Mar 29. [PubMed:15780005 ]
|
