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Showing Protein Alpha-ketoglutarate-dependent dioxygenase FTO (HMDBP12304)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP12304
Secondary Accession Numbers None
Name Alpha-ketoglutarate-dependent dioxygenase FTO
Synonyms
  1. Fat mass and obesity-associated protein
  2. U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
  3. U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO
  4. mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
  5. mRNA N(6)-methyladenosine demethylase FTO
  6. tRNA N1-methyl adenine demethylase FTO
  7. m6A(m)-demethylase FTO
Gene Name FTO
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis (PubMed:22002720, PubMed:26458103, PubMed:28002401, PubMed:30197295, PubMed:26457839, PubMed:25452335). Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:22002720, PubMed:26458103, PubMed:30197295, PubMed:26457839, PubMed:25452335). M6A demethylation by FTO affects mRNA expression and stability (PubMed:30197295). Also able to demethylate m6A in U6 small nuclear RNA (snRNA) (PubMed:30197295). Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating the N(6)-methyladenosine at the second transcribed position of mRNAs and U6 snRNA (PubMed:28002401, PubMed:30197295). Demethylation of m6A(m) in the 5'-cap by FTO affects mRNA stability by promoting susceptibility to decapping (PubMed:28002401). Also acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs (PubMed:30197295). Has no activity towards 1-methylguanine (PubMed:20376003). Has no detectable activity towards double-stranded DNA (PubMed:20376003). Also able to repair alkylated DNA and RNA by oxidative demethylation: demethylates single-stranded RNA containing 3-methyluracil, single-stranded DNA containing 3-methylthymine and has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine (PubMed:18775698, PubMed:20376003). Ability to repair alkylated DNA and RNA is however unsure in vivo (PubMed:18775698, PubMed:20376003). Involved in the regulation of fat mass, adipogenesis and body weight, thereby contributing to the regulation of body size and body fat accumulation (PubMed:18775698, PubMed:20376003). Involved in the regulation of thermogenesis and the control of adipocyte differentiation into brown or white fat cells (PubMed:26287746). Regulates activity of the dopaminergic midbrain circuitry via its ability to demethylate m6A in mRNAs (By similarity). Plays an oncogenic role in a number of acute myeloid leukemias by enhancing leukemic oncogene-mediated cell transformation: acts by mediating m6A demethylation of target transcripts such as MYC, CEBPA, ASB2 and RARA, leading to promote their expression (PubMed:28017614, PubMed:29249359).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
mRNA destabilization
oxidative single-stranded DNA demethylation
oxidative single-stranded RNA demethylation
regulation of brown fat cell differentiation
regulation of lipid storage
DNA dealkylation involved in DNA repair
oxidative demethylation
RNA repair
regulation of multicellular organism growth
DNA demethylation
Cellular Component
cytosol
cytoplasm
plasma membrane
nucleus
nucleoplasm
nuclear speck
intracellular membrane-bounded organelle
Molecular Function
ferrous iron binding
transferase activity
oxidative DNA demethylase activity
oxidative RNA demethylase activity
RNA N6-methyladenosine dioxygenase activity
tRNA demethylase activity
DNA-N1-methyladenine dioxygenase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 505
Molecular Weight 58281.53
Theoretical pI 5.227
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9C0B1
UniProtKB/Swiss-Prot Entry Name FTO_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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