Showing Protein Aconitase htyD (HMDBP12310)
| Identification | |||||
|---|---|---|---|---|---|
| HMDB Protein ID | HMDBP12310 | ||||
| Secondary Accession Numbers | None | ||||
| Name | Aconitase htyD | ||||
| Synonyms |
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| Gene Name | HTYD | ||||
| Protein Type | Unknown | ||||
| Biological Properties | |||||
| General Function | Not Available | ||||
| Specific Function | Aconitase; part of the gene cluster that mediates the de novo generation of L-homotyrosine from acetyl-CoA and 4-hydroxyphenyl-pyruvate (PubMed:22998630). L-homotyrosine is a building block of echinocandin B, a fungal lipidated cyclic hexapeptide that acts as an antifungal agent (PubMed:22998630). L-homotyrosine 4-hydroxyphenyl-pyruvate first undergoes an aldol-type condensation by htyA with the C-2 of acetyl-CoA followed by the release of CoA to form 2-(4-hydroxybenzyl)-malate (PubMed:22998630). This is followed by isomerization of 2-(4-hydroxy-benzyl)-malate to 3-(4-hydroxybenzyl)-malate by htyD (PubMed:22998630). Thereafter, 3-(4-hydroxybenzyl)-malate undergoes decarboxylation and oxidation to form 2-oxo-4-(4-hydroxybenzyl)butanoic acid, coupled to reduction of NAD(+) to NADH by htyC (PubMed:22998630). The product then undergoes transamination catalyzed by htyB to form L-homotyrosine (PubMed:22998630). | ||||
| Pathways | Not Available | ||||
| Reactions | Not Available | ||||
| GO Classification |
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| Cellular Location | Not Available | ||||
| Gene Properties | |||||
| Chromosome Location | Not Available | ||||
| Locus | Not Available | ||||
| SNPs | Not Available | ||||
| Gene Sequence | Not Available | ||||
| Protein Properties | |||||
| Number of Residues | Not Available | ||||
| Molecular Weight | 95012.505 | ||||
| Theoretical pI | Not Available | ||||
| Pfam Domain Function | |||||
| Signals | Not Available | ||||
| Transmembrane Regions | Not Available | ||||
| Protein Sequence | Not Available | ||||
| External Links | |||||
| GenBank ID Protein | Not Available | ||||
| UniProtKB/Swiss-Prot ID | K0E2G4 | ||||
| UniProtKB/Swiss-Prot Entry Name | HTYD_ASPRU | ||||
| PDB IDs | Not Available | ||||
| GenBank Gene ID | Not Available | ||||
| GeneCard ID | Not Available | ||||
| GenAtlas ID | Not Available | ||||
| HGNC ID | Not Available | ||||
| References | |||||
| General References |
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