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Showing Protein Voltage-gated potassium channel subunit beta-2 (HMDBP12315)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 metabolites
Identification
HMDB Protein ID HMDBP12315
Secondary Accession Numbers None
Name Voltage-gated potassium channel subunit beta-2
Synonyms
  1. K(+) channel subunit beta-2
  2. Kv-beta-2
Gene Name KCNAB2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:9763623, PubMed:21357749). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (PubMed:10896669, PubMed:16770729, PubMed:18003609, PubMed:21357749). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:21357749). Modulates the functional properties of KCNA4 (PubMed:9763623). Modulates the functional properties of KCNA5 (By similarity). Enhances KCNB2 channel activity (By similarity). Binds NADPH and has NADPH-dependent aldoketoreductase activity (PubMed:18672894, PubMed:21209188). Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) (PubMed:18672894).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
myoblast differentiation
neuromuscular process
regulation of action potential
regulation of potassium ion transmembrane transport
regulation of protein localization to cell surface
hematopoietic progenitor cell differentiation
NADPH oxidation
Cellular Component
cytosol
cytoskeleton
juxtaparanode region of axon
pinceau fiber
potassium channel complex
voltage-gated potassium channel complex
axon terminus
membrane
neuron projection
axon
postsynaptic density
extrinsic to internal side of plasma membrane
Molecular Function
protein-containing complex binding
D-threo-aldose 1-dehydrogenase activity
ion channel binding
potassium channel regulator activity
voltage-gated potassium channel activity
aldo-keto reductase (NADP) activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 367
Molecular Weight 41020.95
Theoretical pI 8.992
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P62483
UniProtKB/Swiss-Prot Entry Name KCAB2_RAT
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun. 2012 Jun 6;3:876. doi: 10.1038/ncomms1871. [PubMed:22673903 ]
  2. Rettig J, Heinemann SH, Wunder F, Lorra C, Parcej DN, Dolly JO, Pongs O: Inactivation properties of voltage-gated K+ channels altered by presence of beta-subunit. Nature. 1994 May 26;369(6478):289-94. doi: 10.1038/369289a0. [PubMed:8183366 ]
  3. Rhodes KJ, Strassle BW, Monaghan MM, Bekele-Arcuri Z, Matos MF, Trimmer JS: Association and colocalization of the Kvbeta1 and Kvbeta2 beta-subunits with Kv1 alpha-subunits in mammalian brain K+ channel complexes. J Neurosci. 1997 Nov 1;17(21):8246-58. [PubMed:9334400 ]
  4. Accili EA, Kuryshev YA, Wible BA, Brown AM: Separable effects of human Kvbeta1.2 N- and C-termini on inactivation and expression of human Kv1.4. J Physiol. 1998 Oct 15;512 ( Pt 2):325-36. doi: 10.1111/j.1469-7793.1998.325be.x. [PubMed:9763623 ]
  5. Gong J, Xu J, Bezanilla M, van Huizen R, Derin R, Li M: Differential stimulation of PKC phosphorylation of potassium channels by ZIP1 and ZIP2. Science. 1999 Sep 3;285(5433):1565-9. doi: 10.1126/science.285.5433.1565. [PubMed:10477520 ]
  6. Manganas LN, Trimmer JS: Subunit composition determines Kv1 potassium channel surface expression. J Biol Chem. 2000 Sep 22;275(38):29685-93. doi: 10.1074/jbc.M005010200. [PubMed:10896669 ]
  7. Rasband MN, Trimmer JS: Subunit composition and novel localization of K+ channels in spinal cord. J Comp Neurol. 2001 Jan 1;429(1):166-76. doi: 10.1002/1096-9861(20000101)429:1<166::aid-cne13>3.0.co;2-y. [PubMed:11086297 ]
  8. Wang L, Takimoto K, Levitan ES: Differential association of the auxiliary subunit Kvbeta2 with Kv1.4 and Kv4.3 K+ channels. FEBS Lett. 2003 Jul 17;547(1-3):162-4. doi: 10.1016/s0014-5793(03)00705-1. [PubMed:12860406 ]
  9. Plane F, Johnson R, Kerr P, Wiehler W, Thorneloe K, Ishii K, Chen T, Cole W: Heteromultimeric Kv1 channels contribute to myogenic control of arterial diameter. Circ Res. 2005 Feb 4;96(2):216-24. doi: 10.1161/01.RES.0000154070.06421.25. Epub 2004 Dec 23. [PubMed:15618540 ]
  10. Wooten MW, Geetha T, Seibenhener ML, Babu JR, Diaz-Meco MT, Moscat J: The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination. J Biol Chem. 2005 Oct 21;280(42):35625-9. doi: 10.1074/jbc.C500237200. Epub 2005 Aug 3. [PubMed:16079148 ]
  11. Tipparaju SM, Barski OA, Srivastava S, Bhatnagar A: Catalytic mechanism and substrate specificity of the beta-subunit of the voltage-gated potassium channel. Biochemistry. 2008 Aug 26;47(34):8840-54. doi: 10.1021/bi800301b. Epub 2008 Aug 2. [PubMed:18672894 ]
  12. Connors EC, Ballif BA, Morielli AD: Homeostatic regulation of Kv1.2 potassium channel trafficking by cyclic AMP. J Biol Chem. 2008 Feb 8;283(6):3445-3453. doi: 10.1074/jbc.M708875200. Epub 2007 Nov 14. [PubMed:18003609 ]
  13. Vacher H, Yang JW, Cerda O, Autillo-Touati A, Dargent B, Trimmer JS: Cdk-mediated phosphorylation of the Kvbeta2 auxiliary subunit regulates Kv1 channel axonal targeting. J Cell Biol. 2011 Mar 7;192(5):813-24. doi: 10.1083/jcb.201007113. Epub 2011 Feb 28. [PubMed:21357749 ]
  14. Perkowski JJ, Murphy GG: Deletion of the mouse homolog of KCNAB2, a gene linked to monosomy 1p36, results in associative memory impairments and amygdala hyperexcitability. J Neurosci. 2011 Jan 5;31(1):46-54. doi: 10.1523/JNEUROSCI.2634-10.2011. [PubMed:21209188 ]
  15. Ovsepian SV, Steuber V, Le Berre M, O'Hara L, O'Leary VB, Dolly JO: A defined heteromeric KV1 channel stabilizes the intrinsic pacemaking and regulates the output of deep cerebellar nuclear neurons to thalamic targets. J Physiol. 2013 Apr 1;591(7):1771-91. doi: 10.1113/jphysiol.2012.249706. Epub 2013 Jan 14. [PubMed:23318870 ]
  16. Gulbis JM, Zhou M, Mann S, MacKinnon R: Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels. Science. 2000 Jul 7;289(5476):123-7. doi: 10.1126/science.289.5476.123. [PubMed:10884227 ]
  17. Long SB, Campbell EB, Mackinnon R: Crystal structure of a mammalian voltage-dependent Shaker family K+ channel. Science. 2005 Aug 5;309(5736):897-903. doi: 10.1126/science.1116269. Epub 2005 Jul 7. [PubMed:16002581 ]
  18. Long SB, Tao X, Campbell EB, MacKinnon R: Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment. Nature. 2007 Nov 15;450(7168):376-82. doi: 10.1038/nature06265. [PubMed:18004376 ]
  19. Chen X, Wang Q, Ni F, Ma J: Structure of the full-length Shaker potassium channel Kv1.2 by normal-mode-based X-ray crystallographic refinement. Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11352-7. doi: 10.1073/pnas.1000142107. Epub 2010 Jun 3. [PubMed:20534430 ]
  20. Tao X, Lee A, Limapichat W, Dougherty DA, MacKinnon R: A gating charge transfer center in voltage sensors. Science. 2010 Apr 2;328(5974):67-73. doi: 10.1126/science.1185954. [PubMed:20360102 ]
  21. Banerjee A, Lee A, Campbell E, Mackinnon R: Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel. Elife. 2013 May 21;2:e00594. doi: 10.7554/eLife.00594. [PubMed:23705070 ]