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Showing Protein tRNA sulfurtransferase (HMDBP12325)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP12325
Secondary Accession Numbers None
Name tRNA sulfurtransferase
Synonyms
  1. Sulfur carrier protein ThiS sulfurtransferase
  2. Thiamine biosynthesis protein ThiI
  3. tRNA 4-thiouridine synthase
Gene Name THII
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
Pathways
  • Biosynthesis of cofactors
  • Sulfur relay system
  • thiamine diphosphate biosynthesis
  • Thiamine metabolism
Reactions Not Available
GO Classification
Biological Process
tRNA thio-modification
thiamine diphosphate biosynthetic process
thiamine biosynthetic process
thiazole biosynthetic process
Cellular Component
cytoplasm
Molecular Function
tRNA adenylyltransferase activity
ATP binding
sulfurtransferase activity
tRNA binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 482
Molecular Weight 54959.695
Theoretical pI 6.609
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID A1A892
UniProtKB/Swiss-Prot Entry Name THII_ECOK1
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Johnson TJ, Kariyawasam S, Wannemuehler Y, Mangiamele P, Johnson SJ, Doetkott C, Skyberg JA, Lynne AM, Johnson JR, Nolan LK: The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes. J Bacteriol. 2007 Apr;189(8):3228-36. doi: 10.1128/JB.01726-06. Epub 2007 Feb 9. [PubMed:17293413 ]