| Identification |
|---|
| HMDB Protein ID
| HMDBP12329 |
| Secondary Accession Numbers
| None |
| Name
| Probable tRNA sulfurtransferase |
| Synonyms
|
- Sulfur carrier protein ThiS sulfurtransferase
- Thiamine biosynthesis protein ThiI
- tRNA 4-thiouridine synthase
|
| Gene Name
| THII |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. |
| Pathways
|
- Biosynthesis of cofactors
- Sulfur relay system
- thiamine diphosphate biosynthesis
- Thiamine metabolism
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| tRNA thio-modification |
| thiamine diphosphate biosynthetic process |
| thiamine biosynthetic process |
| Cellular Component |
| cytoplasm |
| Molecular Function |
| tRNA adenylyltransferase activity |
| ATP binding |
| sulfurtransferase activity |
| tRNA binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 391 |
| Molecular Weight
| 44464.13 |
| Theoretical pI
| 7.306 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q189U8 |
| UniProtKB/Swiss-Prot Entry Name
| THII_CLOD6 |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Sebaihia M, Wren BW, Mullany P, Fairweather NF, Minton N, Stabler R, Thomson NR, Roberts AP, Cerdeno-Tarraga AM, Wang H, Holden MT, Wright A, Churcher C, Quail MA, Baker S, Bason N, Brooks K, Chillingworth T, Cronin A, Davis P, Dowd L, Fraser A, Feltwell T, Hance Z, Holroyd S, Jagels K, Moule S, Mungall K, Price C, Rabbinowitsch E, Sharp S, Simmonds M, Stevens K, Unwin L, Whithead S, Dupuy B, Dougan G, Barrell B, Parkhill J: The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome. Nat Genet. 2006 Jul;38(7):779-86. Epub 2006 Jun 25. [PubMed:16804543 ]
|
