| Identification |
|---|
| HMDB Protein ID
| HMDBP12355 |
| Secondary Accession Numbers
| None |
| Name
| Aminopyrimidine aminohydrolase |
| Synonyms
|
Not Available
|
| Gene Name
| TENA |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds to give a hydroxymethylpyrimidine (HMP). Displays low activity on 4-amino-5-aminomethyl-2-methylpyrimidine as substrate, indicating that the enzyme may act on a different HMP precursor that may derive from the human stomach food assumption or processing. Is probably involved in thiamine biosynthesis. Does not display thiaminase II activity, as it is unable to hydrolyze thiamine. |
| Pathways
|
- thiamine diphosphate biosynthesis
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| thiamine diphosphate biosynthetic process |
| thiamine biosynthetic process |
| Molecular Function |
| thiaminase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 25012.31 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| A8KRL3 |
| UniProtKB/Swiss-Prot Entry Name
| TENA_HELPX |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Barison N, Cendron L, Trento A, Angelini A, Zanotti G: Structural and mutational analysis of TenA protein (HP1287) from the Helicobacter pylori thiamin salvage pathway - evidence of a different substrate specificity. FEBS J. 2009 Nov;276(21):6227-35. doi: 10.1111/j.1742-4658.2009.07326.x. Epub 2009 Sep 23. [PubMed:19780837 ]
|
