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Showing Protein Beta-2-glycoprotein 1 (HMDBP12361)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP12361
Secondary Accession Numbers None
Name Beta-2-glycoprotein 1
Synonyms
  1. APC inhibitor
  2. Activated protein C-binding protein
  3. Apolipoprotein H
  4. Beta-2-glycoprotein I
  5. Apo-H
  6. B2GPI
  7. Beta(2)GPI
Gene Name APOH
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
Pathways
  • Cholesterol metabolism
Reactions Not Available
GO Classification
Biological Process
organ regeneration
positive regulation of triglyceride catabolic process
blood coagulation
negative regulation of endothelial cell migration
positive regulation of lipoprotein lipase activity
negative regulation of endothelial cell proliferation
blood coagulation, intrinsic pathway
negative regulation of fibrinolysis
negative regulation of myeloid cell apoptotic process
negative regulation of respiratory burst
negative regulation of smooth muscle cell apoptotic process
regulation of blood coagulation
regulation of fibrinolysis
triglyceride transport
negative regulation of angiogenesis
negative regulation of blood coagulation
plasminogen activation
triglyceride metabolic process
Cellular Component
cell surface
cytoplasm
high-density lipoprotein particle
plasma membrane
chylomicron
very-low-density lipoprotein particle
extracellular space
Molecular Function
lipid binding
phospholipid binding
lipoprotein lipase activator activity
heparin binding
identical protein binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 345
Molecular Weight 38618.49
Theoretical pI 8.215
Pfam Domain Function
Signals
  • 1-19;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q01339
UniProtKB/Swiss-Prot Entry Name APOH_MOUSE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP: A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001. [PubMed:21183079 ]
  3. Nonaka M, Matsuda Y, Shiroishi T, Moriwaki K, Nonaka M, Natsuume-Sakai S: Molecular cloning of mouse beta 2-glycoprotein I and mapping of the gene to chromosome 11. Genomics. 1992 Aug;13(4):1082-7. doi: 10.1016/0888-7543(92)90022-k. [PubMed:1339387 ]
  4. Sellar GC, Steel DM, Zafiropoulos A, Seery LT, Whitehead AS: Characterization, expression and evolution of mouse beta 2-glycoprotein I (apolipoprotein H). Biochem Biophys Res Commun. 1994 May 16;200(3):1521-8. doi: 10.1006/bbrc.1994.1623. [PubMed:7514402 ]
  5. Ghesquiere B, Van Damme J, Martens L, Vandekerckhove J, Gevaert K: Proteome-wide characterization of N-glycosylation events by diagonal chromatography. J Proteome Res. 2006 Sep;5(9):2438-47. doi: 10.1021/pr060186m. [PubMed:16944957 ]
  6. Bernhard OK, Kapp EA, Simpson RJ: Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides. J Proteome Res. 2007 Mar;6(3):987-95. doi: 10.1021/pr0604559. [PubMed:17330941 ]