Hmdb loader

Showing Protein Choline O-acetyltransferase (HMDBP12363)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP12363
Secondary Accession Numbers None
Name Choline O-acetyltransferase
Synonyms
  1. CHOACTase
  2. ChAT
  3. Choline acetylase
Gene Name CHAT
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
Pathways
  • Cholinergic synapse
  • Glycerophospholipid metabolism
Reactions Not Available
GO Classification
Biological Process
neurotransmitter biosynthetic process
Molecular Function
choline O-acetyltransferase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 641
Molecular Weight 71729.95
Theoretical pI 7.524
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P13222
UniProtKB/Swiss-Prot Entry Name CLAT_PIG
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Berrard S, Brice A, Lottspeich F, Braun A, Barde YA, Mallet J: cDNA cloning and complete sequence of porcine choline acetyltransferase: in vitro translation of the corresponding RNA yields an active protein. Proc Natl Acad Sci U S A. 1987 Dec;84(24):9280-4. doi: 10.1073/pnas.84.24.9280. [PubMed:3480542 ]
  2. Berrard S, Brice A, Mallet J: Molecular genetic approach to the study of mammalian choline acetyltransferase. Brain Res Bull. 1989 Jan;22(1):147-53. doi: 10.1016/0361-9230(89)90139-1. [PubMed:2713713 ]
  3. Hersh LB, Kong CF, Sampson C, Mues G, Li YP, Fisher A, Hilt D, Baetge EE: Comparison of the promoter region of the human and porcine choline acetyltransferase genes: localization of an important enhancer region. J Neurochem. 1993 Jul;61(1):306-14. doi: 10.1111/j.1471-4159.1993.tb03569.x. [PubMed:8515278 ]
  4. Braun A, Barde YA, Lottspeich F, Mewes W, Thoenen H: N-terminal sequence of pig brain choline acetyltransferase purified by a rapid procedure. J Neurochem. 1987 Jan;48(1):16-21. doi: 10.1111/j.1471-4159.1987.tb13121.x. [PubMed:3794697 ]