Hmdb loader
Identification
HMDB Protein ID HMDBP12371
Secondary Accession Numbers None
Name Toll-like receptor 13
Synonyms Not Available
Gene Name TLR13
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Component of innate and adaptive immunity that recognizes and binds 23S rRNA from bacteria. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Specifically binds the 5'-CGGAAAGACC-3' sequence on bacterial 23S rRNA, a sequence also bound by MLS group antibiotics (including erythromycin). May also recognize vesicular stomatitis virus; however, these data require additional evidences.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
inflammatory response
response to virus
innate immune response
regulation of MAPK cascade
toll-like receptor 13 signaling pathway
toll-like receptor signaling pathway
MyD88-dependent toll-like receptor signaling pathway
Cellular Component
cytoplasm
endosome membrane
integral to plasma membrane
endosome
Molecular Function
transmembrane signaling receptor activity
NAD(P)+ nucleosidase activity
NAD+ nucleotidase, cyclic ADP-ribose generating
signaling receptor activity
identical protein binding
rRNA binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 991
Molecular Weight 114441.44
Theoretical pI 8.627
Pfam Domain Function
Signals
  • 1-68;
Transmembrane Regions
  • 784-804;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q6R5N8
UniProtKB/Swiss-Prot Entry Name TLR13_MOUSE
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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