Hmdb loader
Identification
HMDB Protein ID HMDBP12383
Secondary Accession Numbers None
Name Toll-like receptor 10
Synonyms Not Available
Gene Name TLR10
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
regulation of cytokine production
positive regulation of inflammatory response
inflammatory response
innate immune response
immune response
toll-like receptor signaling pathway
toll-like receptor 10 signaling pathway
MyD88-dependent toll-like receptor signaling pathway
Cellular Component
plasma membrane
membrane
integral to plasma membrane
Molecular Function
transmembrane signaling receptor activity
NAD(P)+ nucleosidase activity
NAD+ nucleotidase, cyclic ADP-ribose generating
signaling receptor activity
identical protein binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 811
Molecular Weight 94563.47
Theoretical pI 6.791
Pfam Domain Function
Signals
  • 1-19;
Transmembrane Regions
  • 577-597;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9BXR5
UniProtKB/Swiss-Prot Entry Name TLR10_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  3. Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. 2003 Oct;13(10):2265-70. Epub 2003 Sep 15. [PubMed:12975309 ]
  4. Nakajima T, Ohtani H, Satta Y, Uno Y, Akari H, Ishida T, Kimura A: Natural selection in the TLR-related genes in the course of primate evolution. Immunogenetics. 2008 Dec;60(12):727-35. doi: 10.1007/s00251-008-0332-0. Epub 2008 Sep 23. [PubMed:18810425 ]
  5. Chuang T, Ulevitch RJ: Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells. Biochim Biophys Acta. 2001 Mar 19;1518(1-2):157-61. doi: 10.1016/s0167-4781(00)00289-x. [PubMed:11267672 ]
  6. Georgel P, Macquin C, Bahram S: The heterogeneous allelic repertoire of human toll-like receptor (TLR) genes. PLoS One. 2009 Nov 17;4(11):e7803. doi: 10.1371/journal.pone.0007803. [PubMed:19924287 ]
  7. Nyman T, Stenmark P, Flodin S, Johansson I, Hammarstrom M, Nordlund P: The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer. J Biol Chem. 2008 May 2;283(18):11861-5. doi: 10.1074/jbc.C800001200. Epub 2008 Mar 10. [PubMed:18332149 ]