Hmdb loader
Identification
HMDB Protein ID HMDBP12385
Secondary Accession Numbers None
Name Poly(ADP-ribose) glycohydrolase
Synonyms Not Available
Gene Name PARG
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers. It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated. Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG. Required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress, while it is not required for recovery from transient replicative stress. Responsible for the prevalence of mono-ADP-ribosylated proteins in cells, thanks to its ability to degrade poly(ADP-ribose) without cleaving the terminal protein-ribose bond. Required for retinoid acid-dependent gene transactivation, probably by removing poly(ADP-ribose) from histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters. Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
detection of bacterium
response to DNA damage stimulus
positive regulation of DNA repair
regulation of DNA repair
ATP generation from poly-ADP-D-ribose
regulation of histone modification
carbohydrate metabolic process
nucleotide-sugar metabolic process
Cellular Component
cytosol
cytoplasm
nucleus
nucleoplasm
chromatin
intracellular membrane-bounded organelle
Molecular Function
chromatin binding
poly(ADP-ribose) glycohydrolase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 109322.71
Theoretical pI Not Available
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O88622
UniProtKB/Swiss-Prot Entry Name PARG_MOUSE
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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