Hmdb loader
Identification
HMDB Protein ID HMDBP12397
Secondary Accession Numbers None
Name X-linked interleukin-1 receptor accessory protein-like 2
Synonyms
  1. IL-1 receptor accessory protein-like 2
  2. IL-1-RAPL-2
  3. IL-1RAPL-2
  4. IL1RAPL-2
  5. IL1RAPL-2-related protein
  6. Interleukin-1 receptor 9
  7. Three immunoglobulin domain-containing IL-1 receptor-related 1
  8. IL-1R-9
  9. IL-1R9
  10. TIGIRR-1
Gene Name IL1RAPL2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Not Available
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
regulation of presynapse assembly
central nervous system development
Cellular Component
plasma membrane
glutamatergic synapse
integral to membrane
Molecular Function
NAD(P)+ nucleosidase activity
NAD+ nucleotidase, cyclic ADP-ribose generating
interleukin-1 receptor activity
interleukin-1, type II, blocking receptor activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 686
Molecular Weight 78669.095
Theoretical pI 6.456
Pfam Domain Function
Signals
  • 1-16;
Transmembrane Regions
  • 355-375;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9NP60
UniProtKB/Swiss-Prot Entry Name IRPL2_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  4. Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE: The consensus coding sequences of human breast and colorectal cancers. Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7. [PubMed:16959974 ]
  5. Born TL, Smith DE, Garka KE, Renshaw BR, Bertles JS, Sims JE: Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling. J Biol Chem. 2000 Sep 29;275(39):29946-54. doi: 10.1074/jbc.M004077200. [PubMed:10882729 ]
  6. Sana TR, Debets R, Timans JC, Bazan JF, Kastelein RA: Computational identification, cloning, and characterization of IL-1R9, a novel interleukin-1 receptor-like gene encoded over an unusually large interval of human chromosome Xq22.2-q22.3. Genomics. 2000 Oct 15;69(2):252-62. doi: 10.1006/geno.2000.6328. [PubMed:11031108 ]
  7. Ferrante MI, Ghiani M, Bulfone A, Franco B: IL1RAPL2 maps to Xq22 and is specifically expressed in the central nervous system. Gene. 2001 Sep 19;275(2):217-21. doi: 10.1016/s0378-1119(01)00659-x. [PubMed:11587848 ]
  8. Jin H, Gardner RJ, Viswesvaraiah R, Muntoni F, Roberts RG: Two novel members of the interleukin-1 receptor gene family, one deleted in Xp22.1-Xp21.3 mental retardation. Eur J Hum Genet. 2000 Feb;8(2):87-94. doi: 10.1038/sj.ejhg.5200415. [PubMed:10757639 ]