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Showing Protein Interleukin-1 receptor accessory protein (HMDBP12401)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP12401
Secondary Accession Numbers None
Name Interleukin-1 receptor accessory protein
Synonyms
  1. IL-1 receptor accessory protein
  2. IL-1RAcP
  3. Interleukin-1 receptor 3
  4. IL-1R-3
  5. IL-1R3
Gene Name IL1RAP
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable).Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (PubMed:12530978). Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling (By similarity).Unable to mediate canonical IL-1 signaling (PubMed:19481478). Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons (By similarity).
Pathways
  • Cytokine-cytokine receptor interaction
  • Inflammatory mediator regulation of TRP channels
  • MAPK signaling pathway
  • Th17 cell differentiation
Reactions Not Available
GO Classification
Biological Process
inflammatory response
interleukin-1-mediated signaling pathway
innate immune response
immune response
cytokine-mediated signaling pathway
positive regulation of interleukin-6 production
positive regulation of NF-kappaB transcription factor activity
regulation of presynapse assembly
protein-containing complex assembly
interleukin-33-mediated signaling pathway
positive regulation of interleukin-13 production
positive regulation of interleukin-4 production
positive regulation of interleukin-5 production
positive regulation of synapse assembly
regulation of postsynaptic density assembly
synaptic membrane adhesion
trans-synaptic signaling by trans-synaptic complex
Cellular Component
plasma membrane
extracellular region
glutamatergic synapse
membrane
integral to plasma membrane
Molecular Function
NAD(P)+ nucleosidase activity
NAD+ nucleotidase, cyclic ADP-ribose generating
interleukin-1 receptor activity
interleukin-1 receptor binding
interleukin-33 receptor activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 570
Molecular Weight 65417.925
Theoretical pI 8.115
Pfam Domain Function
Signals
  • 1-20;
Transmembrane Regions
  • 368-388;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9NPH3
UniProtKB/Swiss-Prot Entry Name IL1AP_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  8. Tominaga K, Yoshimoto T, Torigoe K, Kurimoto M, Matsui K, Hada T, Okamura H, Nakanishi K: IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells. Int Immunol. 2000 Feb;12(2):151-60. doi: 10.1093/intimm/12.2.151. [PubMed:10653850 ]
  9. Huang J, Gao X, Li S, Cao Z: Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein. Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):12829-32. doi: 10.1073/pnas.94.24.12829. [PubMed:9371760 ]
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