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Identification
HMDB Protein ID HMDBP12408
Secondary Accession Numbers None
Name Interleukin-1 receptor-like 1
Synonyms
  1. Protein ST2
Gene Name IL1RL1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.Inhibits IL-33 signaling.
Pathways
  • Cytokine-cytokine receptor interaction
Reactions Not Available
GO Classification
Biological Process
negative regulation of T-helper 1 type immune response
signal transduction
positive regulation of chemokine production
negative regulation of interferon-gamma production
positive regulation of inflammatory response
immune response
positive regulation of macrophage activation
interleukin-33-mediated signaling pathway
positive regulation of interleukin-5 production
Cellular Component
cytosol
focal adhesion
plasma membrane
extracellular region
external side of plasma membrane
integral to membrane
Molecular Function
cytokine receptor activity
interleukin-33 binding
NAD(P)+ nucleosidase activity
NAD+ nucleotidase, cyclic ADP-ribose generating
interleukin-1 receptor activity
interleukin-33 receptor activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 556
Molecular Weight 63357.345
Theoretical pI 8.346
Pfam Domain Function
Signals
  • 1-18;
Transmembrane Regions
  • 329-349;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q01638
UniProtKB/Swiss-Prot Entry Name ILRL1_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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