Hmdb loader
Identification
HMDB Protein ID HMDBP12409
Secondary Accession Numbers None
Name Interleukin-18 receptor accessory protein
Synonyms
  1. IL-18 receptor accessory protein
  2. IL-18RAcP
  3. Accessory protein-like
  4. CD218 antigen-like family member B
  5. CDw218b
  6. IL-1R accessory protein-like
  7. Interleukin-1 receptor 7
  8. Interleukin-18 receptor accessory protein-like
  9. Interleukin-18 receptor beta
  10. AcPL
  11. IL-1RAcPL
  12. IL-1R-7
  13. IL-1R7
  14. IL-18R-beta
  15. IL-18Rbeta
Gene Name IL18RAP
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation (PubMed:9792649, PubMed:14528293, PubMed:25500532). May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable).
Pathways
  • Cytokine-cytokine receptor interaction
  • Inflammatory bowel disease
  • Viral protein interaction with cytokine and cytokine receptor
Reactions Not Available
GO Classification
Biological Process
cell proliferation
inflammatory response
immune response
positive regulation of natural killer cell mediated cytotoxicity
positive regulation of NF-kappaB transcription factor activity
cellular response to hydrogen peroxide
interleukin-18-mediated signaling pathway
neutrophil activation
Cellular Component
plasma membrane
interleukin-18 receptor complex
Molecular Function
NAD(P)+ nucleosidase activity
NAD+ nucleotidase, cyclic ADP-ribose generating
interleukin-18 receptor activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 599
Molecular Weight 68308.99
Theoretical pI 8.381
Pfam Domain Function
Signals
  • 1-19;
Transmembrane Regions
  • 357-377;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O95256
UniProtKB/Swiss-Prot Entry Name I18RA_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 2005 Apr 7;434(7034):724-31. [PubMed:15815621 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Tominaga K, Yoshimoto T, Torigoe K, Kurimoto M, Matsui K, Hada T, Okamura H, Nakanishi K: IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells. Int Immunol. 2000 Feb;12(2):151-60. doi: 10.1093/intimm/12.2.151. [PubMed:10653850 ]
  4. Sareneva T, Julkunen I, Matikainen S: IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells. J Immunol. 2000 Aug 15;165(4):1933-8. doi: 10.4049/jimmunol.165.4.1933. [PubMed:10925275 ]
  5. Debets R, Timans JC, Churakowa T, Zurawski S, de Waal Malefyt R, Moore KW, Abrams JS, O'Garra A, Bazan JF, Kastelein RA: IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18. J Immunol. 2000 Nov 1;165(9):4950-6. doi: 10.4049/jimmunol.165.9.4950. [PubMed:11046021 ]
  6. Tsutsumi N, Kimura T, Arita K, Ariyoshi M, Ohnishi H, Yamamoto T, Zuo X, Maenaka K, Park EY, Kondo N, Shirakawa M, Tochio H, Kato Z: The structural basis for receptor recognition of human interleukin-18. Nat Commun. 2014 Dec 15;5:5340. doi: 10.1038/ncomms6340. [PubMed:25500532 ]
  7. Born TL, Thomassen E, Bird TA, Sims JE: Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling. J Biol Chem. 1998 Nov 6;273(45):29445-50. doi: 10.1074/jbc.273.45.29445. [PubMed:9792649 ]
  8. Fiszer D, Rozwadowska N, Rychlewski L, Kosicki W, Kurpisz M: Identification of IL-18RAP mRNA truncated splice variants in human testis and the other human tissues. Cytokine. 2007 Sep;39(3):178-83. doi: 10.1016/j.cyto.2007.07.186. Epub 2007 Sep 25. [PubMed:17897836 ]
  9. Kato Z, Jee J, Shikano H, Mishima M, Ohki I, Ohnishi H, Li A, Hashimoto K, Matsukuma E, Omoya K, Yamamoto Y, Yoneda T, Hara T, Kondo N, Shirakawa M: The structure and binding mode of interleukin-18. Nat Struct Biol. 2003 Nov;10(11):966-71. doi: 10.1038/nsb993. Epub 2003 Oct 5. [PubMed:14528293 ]