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Showing Protein Interleukin-1 receptor type 1 (HMDBP12410)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP12410
Secondary Accession Numbers None
Name Interleukin-1 receptor type 1
Synonyms
  1. IL-1R-1
  2. IL-1RT-1
  3. IL-1RT1
  4. CD121 antigen-like family member A
  5. Interleukin-1 receptor alpha
  6. Interleukin-1 receptor type I
  7. p80
  8. IL-1R-alpha
Gene Name IL1R1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850).
Pathways
  • Amoebiasis
  • Cytokine-cytokine receptor interaction
  • Fluid shear stress and atherosclerosis
  • Hematopoietic cell lineage
  • Human cytomegalovirus infection
  • Human T-cell leukemia virus 1 infection
  • Inflammatory mediator regulation of TRP channels
  • MAPK signaling pathway
  • NF-kappa B signaling pathway
  • Osteoclast differentiation
  • Pathogenic Escherichia coli infection
  • Shigellosis
  • Th17 cell differentiation
Reactions Not Available
GO Classification
Biological Process
positive regulation of interleukin-1-mediated signaling pathway
positive regulation of neutrophil extravasation
regulation of inflammatory response
response to interleukin-1
inflammatory response
interleukin-1-mediated signaling pathway
cell surface receptor signaling pathway
immune response
cytokine-mediated signaling pathway
positive regulation of interferon-gamma production
positive regulation of T-helper 1 cell cytokine production
Cellular Component
plasma membrane
extracellular region
external side of plasma membrane
membrane
integral to plasma membrane
Molecular Function
interleukin-1 binding
protease binding
platelet-derived growth factor receptor binding
transmembrane signaling receptor activity
NAD(P)+ nucleosidase activity
NAD+ nucleotidase, cyclic ADP-ribose generating
interleukin-1 receptor activity
interleukin-1, type I, activating receptor activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 569
Molecular Weight 65401.91
Theoretical pI 7.819
Pfam Domain Function
Signals
  • 1-17;
Transmembrane Regions
  • 337-356;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P14778
UniProtKB/Swiss-Prot Entry Name IL1R1_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  3. Vigers GP, Anderson LJ, Caffes P, Brandhuber BJ: Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta. Nature. 1997 Mar 13;386(6621):190-4. [PubMed:9062193 ]
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  6. Huang J, Gao X, Li S, Cao Z: Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein. Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):12829-32. doi: 10.1073/pnas.94.24.12829. [PubMed:9371760 ]
  7. Chua AO, Gubler U: Sequence of the cDNA for the human fibroblast type interleukin-1 receptor. Nucleic Acids Res. 1989 Dec 11;17(23):10114. doi: 10.1093/nar/17.23.10114. [PubMed:2532321 ]
  8. Sims JE, Acres RB, Grubin CE, McMahan CJ, Wignall JM, March CJ, Dower SK: Cloning the interleukin 1 receptor from human T cells. Proc Natl Acad Sci U S A. 1989 Nov;86(22):8946-50. doi: 10.1073/pnas.86.22.8946. [PubMed:2530587 ]
  9. Svenson M, Hansen MB, Heegaard P, Abell K, Bendtzen K: Specific binding of interleukin 1 (IL-1) beta and IL-1 receptor antagonist (IL-1ra) to human serum. High-affinity binding of IL-1ra to soluble IL-1 receptor type I. Cytokine. 1993 Sep;5(5):427-35. doi: 10.1016/1043-4666(93)90032-z. [PubMed:8142597 ]
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