Hmdb loader

Showing Protein Protransforming growth factor alpha (HMDBP12416)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP12416
Secondary Accession Numbers None
Name Protransforming growth factor alpha
Synonyms Not Available
Gene Name TGFA
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
Pathways
  • Colorectal cancer
  • EGFR tyrosine kinase inhibitor resistance
  • ErbB signaling pathway
  • Estrogen signaling pathway
  • Glioma
  • Hepatocellular carcinoma
  • MAPK signaling pathway
  • Non-small cell lung cancer
  • Pancreatic cancer
  • PI3K-Akt signaling pathway
  • Prostate cancer
  • Ras signaling pathway
  • Renal cell carcinoma
Reactions Not Available
GO Classification
Biological Process
signal transduction
positive regulation of cell proliferation
COPII vesicle coating
membrane organization
positive regulation of epidermal growth factor-activated receptor activity
ER to Golgi vesicle-mediated transport
positive regulation of mitotic nuclear division
regulation of transcription from RNA polymerase II promoter
negative regulation of epidermal growth factor receptor signaling pathway
positive regulation of protein kinase B signaling cascade
MAPK cascade
positive regulation of epithelial cell proliferation
positive regulation of cell division
epidermal growth factor receptor signaling pathway
intracellular signal transduction
activation of MAPK activity
Cellular Component
endoplasmic reticulum membrane
cell surface
clathrin-coated endocytic vesicle membrane
endoplasmic reticulum-Golgi intermediate compartment membrane
ER to Golgi transport vesicle membrane
plasma membrane
perinuclear region of cytoplasm
basolateral plasma membrane
extracellular region
extracellular space
cytoplasmic vesicle
integral to membrane
Molecular Function
epidermal growth factor receptor binding
growth factor activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 160
Molecular Weight 17005.785
Theoretical pI 7.539
Pfam Domain Function Not Available
Signals
  • 1-23;
Transmembrane Regions
  • 99-124;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P01135
UniProtKB/Swiss-Prot Entry Name TGFA_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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