Hmdb loader
Identification
HMDB Protein ID HMDBP12434
Secondary Accession Numbers None
Name Alpha-conotoxin ImII
Synonyms
  1. Alpha-CTx ImII
Gene Name Not Available
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks neuronal mammalian alpha-7 (human and rat) and alpha-3/beta-2 (human) and muscle alpha-1-beta-1-delta-epsilon (human) nAChRs (PubMed:12384509, PubMed:15609996). Acts voltage-independently (PubMed:12384509). Does not competes with alpha-bungarotoxin for binding to the receptor (PubMed:12384509, PubMed:15609996). Binds to a different site than alpha-conotoxin ImI (PubMed:15609996).
Pathways Not Available
Reactions Not Available
GO Classification
Cellular Component
host cell postsynaptic membrane
extracellular region
Molecular Function
toxin activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 2096.46
Theoretical pI Not Available
Pfam Domain Function Not Available
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q8I6R5
UniProtKB/Swiss-Prot Entry Name CA12_CONIM
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Ellison M, McIntosh JM, Olivera BM: Alpha-conotoxins ImI and ImII. Similar alpha 7 nicotinic receptor antagonists act at different sites. J Biol Chem. 2003 Jan 10;278(2):757-64. doi: 10.1074/jbc.M204565200. Epub 2002 Oct 15. [PubMed:12384509 ]
  2. Ellison M, Gao F, Wang HL, Sine SM, McIntosh JM, Olivera BM: Alpha-conotoxins ImI and ImII target distinct regions of the human alpha7 nicotinic acetylcholine receptor and distinguish human nicotinic receptor subtypes. Biochemistry. 2004 Dec 28;43(51):16019-26. doi: 10.1021/bi048918g. [PubMed:15609996 ]