Hmdb loader

Showing Protein Translocator protein (HMDBP12625)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP12625
Secondary Accession Numbers None
Name Translocator protein
Synonyms
  1. Mitochondrial benzodiazepine receptor
  2. PKBS
  3. Peripheral-type benzodiazepine receptor
  4. PBR
Gene Name TSPO
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides. Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:9832438, PubMed:24814875), but its precise physiological role is controversial. According to some reports, it is not required for steroid hormone biosynthesis (PubMed:24174323, PubMed:24936060).
Pathways
  • Cholesterol metabolism
  • Human T-cell leukemia virus 1 infection
  • Neuroactive ligand-receptor interaction
Reactions Not Available
GO Classification
Biological Process
positive regulation of reactive oxygen species metabolic process
ion transport
positive regulation of apoptotic process
response to progesterone stimulus
negative regulation of protein ubiquitination
adrenal gland development
negative regulation of tumor necrosis factor production
response to testosterone stimulus
steroid biosynthetic process
response to drug
positive regulation of mitochondrial depolarization
negative regulation of nitric oxide biosynthetic process
cellular response to lipopolysaccharide
contact inhibition
behavioral response to pain
cellular hypotonic response
cellular response to zinc ion
chloride transport
establishment of protein localization to mitochondrion
glial cell migration
maintenance of protein location in mitochondrion
positive regulation of calcium ion transport
negative regulation of ATP metabolic process
negative regulation of autophagy of mitochondrion
negative regulation of glial cell proliferation
negative regulation of mitochondrion organization
positive regulation of glial cell proliferation
positive regulation of necrotic cell death
regulation of steroid biosynthetic process
response to vitamin B1
lipid transport
peripheral nervous system axon regeneration
aging
response to manganese ion
Cellular Component
cytosol
endoplasmic reticulum
mitochondrion
mitochondrial outer membrane
intracellular membrane-bounded organelle
integral to membrane
Molecular Function
cholesterol binding
ion channel binding
benzodiazepine receptor activity
androgen binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 169
Molecular Weight 18840.7
Theoretical pI 9.523
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 6-26;47-67;80-100;106-126;135-155;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P50637
UniProtKB/Swiss-Prot Entry Name TSPO_MOUSE
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schonbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y: The transcriptional landscape of the mammalian genome. Science. 2005 Sep 2;309(5740):1559-63. [PubMed:16141072 ]
  3. Yakovlev AG, Ruffo M, Jurka J, Krueger KE: Comparison of repetitive elements in the third intron of human and rodent mitochondrial benzodiazepine receptor-encoding genes. Gene. 1995 Apr 3;155(2):201-5. [PubMed:7721091 ]
  4. Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP: A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001. [PubMed:21183079 ]
  5. Garnier M, Dimchev AB, Boujrad N, Price JM, Musto NA, Papadopoulos V: In vitro reconstitution of a functional peripheral-type benzodiazepine receptor from mouse Leydig tumor cells. Mol Pharmacol. 1994 Feb;45(2):201-11. [PubMed:8114671 ]
  6. Taketani S, Kohno H, Okuda M, Furukawa T, Tokunaga R: Induction of peripheral-type benzodiazepine receptors during differentiation of mouse erythroleukemia cells. A possible involvement of these receptors in heme biosynthesis. J Biol Chem. 1994 Mar 11;269(10):7527-31. [PubMed:8125973 ]
  7. Ehringer MA, Thompson J, Conroy O, Xu Y, Yang F, Canniff J, Beeson M, Gordon L, Bennett B, Johnson TE, Sikela JM: High-throughput sequence identification of gene coding variants within alcohol-related QTLs. Mamm Genome. 2001 Aug;12(8):657-63. doi: 10.1007/s00335-001-1001-x. [PubMed:11471062 ]
  8. Li H, Papadopoulos V: Peripheral-type benzodiazepine receptor function in cholesterol transport. Identification of a putative cholesterol recognition/interaction amino acid sequence and consensus pattern. Endocrinology. 1998 Dec;139(12):4991-7. doi: 10.1210/endo.139.12.6390. [PubMed:9832438 ]
  9. Taylor JM, Allen AM, Graham A: Targeting mitochondrial 18 kDa translocator protein (TSPO) regulates macrophage cholesterol efflux and lipid phenotype. Clin Sci (Lond). 2014 Nov;127(10):603-13. doi: 10.1042/CS20140047. [PubMed:24814875 ]
  10. Morohaku K, Pelton SH, Daugherty DJ, Butler WR, Deng W, Selvaraj V: Translocator protein/peripheral benzodiazepine receptor is not required for steroid hormone biosynthesis. Endocrinology. 2014 Jan;155(1):89-97. doi: 10.1210/en.2013-1556. Epub 2013 Dec 20. [PubMed:24174323 ]
  11. Tu LN, Morohaku K, Manna PR, Pelton SH, Butler WR, Stocco DM, Selvaraj V: Peripheral benzodiazepine receptor/translocator protein global knock-out mice are viable with no effects on steroid hormone biosynthesis. J Biol Chem. 2014 Oct 3;289(40):27444-54. doi: 10.1074/jbc.M114.578286. Epub 2014 Jun 16. [PubMed:24936060 ]
  12. Jaremko L, Jaremko M, Giller K, Becker S, Zweckstetter M: Structure of the mitochondrial translocator protein in complex with a diagnostic ligand. Science. 2014 Mar 21;343(6177):1363-6. doi: 10.1126/science.1248725. [PubMed:24653034 ]
  13. Jaremko M, Jaremko L, Giller K, Becker S, Zweckstetter M: Structural Integrity of the A147T Polymorph of Mammalian TSPO. Chembiochem. 2015 Jul 6;16(10):1483-9. doi: 10.1002/cbic.201500217. Epub 2015 Jun 10. [PubMed:25974690 ]