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Showing Protein Protein shisa-7 (HMDBP12627)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP12627
Secondary Accession Numbers None
Name Protein shisa-7
Synonyms
  1. Cystine-knot AMPAR modulating protein of 59 kDa
  2. GABA(A) receptor auxiliary subunit Shisa7
  3. Protein shisa-6-like
  4. CKAMP59
Gene Name SHISA7
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Transmembrane protein that regulates gamma-aminobutyric acid type A receptor (GABA(A)R) trafficking, channel deactivation kinetics and pharmacology, necessary for fast inhibitory transmission in the brain. Enhances the action of benzodiazepine, a primary GABA(A)Rs target drug, in the brain. May affect channel kinetics of AMPA-type glutamate receptors (AMPAR), the brain's main excitatory neurotransmitter, necessary for synaptic hippocampal plasticity, and memory recall. May regulate the induction and maintenance of long-term potentiation at Schaffer collaterals/CA3-CA1 excitatory synapses.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
memory
gamma-aminobutyric acid receptor clustering
gamma-aminobutyric acid signaling pathway
positive regulation of long-term synaptic potentiation
regulation of AMPA glutamate receptor clustering
regulation of AMPA receptor activity
regulation of GABA-A receptor activity
regulation of short-term neuronal synaptic plasticity
Cellular Component
postsynaptic membrane
dendritic spine membrane
AMPA glutamate receptor complex
asymmetric, glutamatergic, excitatory synapse
postsynaptic density membrane
postsynaptic density
Molecular Function
GABA receptor binding
ionotropic glutamate receptor binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 538
Molecular Weight 56213.015
Theoretical pI 10.024
Pfam Domain Function
Signals
  • 1-19;
Transmembrane Regions
  • 187-207;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID A6NL88
UniProtKB/Swiss-Prot Entry Name SHSA7_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Grimwood J, Gordon LA, Olsen A, Terry A, Schmutz J, Lamerdin J, Hellsten U, Goodstein D, Couronne O, Tran-Gyamfi M, Aerts A, Altherr M, Ashworth L, Bajorek E, Black S, Branscomb E, Caenepeel S, Carrano A, Caoile C, Chan YM, Christensen M, Cleland CA, Copeland A, Dalin E, Dehal P, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Garcia C, Georgescu AM, Glavina T, Gomez M, Gonzales E, Groza M, Hammon N, Hawkins T, Haydu L, Ho I, Huang W, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Larionov V, Leem SH, Lopez F, Lou Y, Lowry S, Malfatti S, Martinez D, McCready P, Medina C, Morgan J, Nelson K, Nolan M, Ovcharenko I, Pitluck S, Pollard M, Popkie AP, Predki P, Quan G, Ramirez L, Rash S, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, She X, Smith D, Slezak T, Solovyev V, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wagner M, Wheeler J, Wu K, Xie G, Yang J, Dubchak I, Furey TS, DeJong P, Dickson M, Gordon D, Eichler EE, Pennacchio LA, Richardson P, Stubbs L, Rokhsar DS, Myers RM, Rubin EM, Lucas SM: The DNA sequence and biology of human chromosome 19. Nature. 2004 Apr 1;428(6982):529-35. [PubMed:15057824 ]