| Identification |
|---|
| HMDB Protein ID
| HMDBP12630 |
| Secondary Accession Numbers
| None |
| Name
| Acyl-CoA-binding protein |
| Synonyms
|
- ACBP
- Diazepam-binding inhibitor
- Endozepine
- DBI
- EP
|
| Gene Name
| DBI |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor. |
| Pathways
|
|
| Reactions
| Not Available |
| GO Classification
|
| Cellular Component |
| endoplasmic reticulum |
| Golgi apparatus |
| Molecular Function |
| lipid binding |
| fatty-acyl-CoA binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 87 |
| Molecular Weight
| 10044.4 |
| Theoretical pI
| 6.564 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P07107 |
| UniProtKB/Swiss-Prot Entry Name
| ACBP_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Webb NR, Rose TM, Malik N, Marquardt H, Shoyab M, Todaro GJ, Lee DC: Bovine and human cDNA sequences encoding a putative benzodiazepine receptor ligand. DNA. 1987 Feb;6(1):71-9. [PubMed:2881742 ]
- Marquardt H, Todaro GJ, Shoyab M: Complete amino acid sequences of bovine and human endozepines. Homology with rat diazepam binding inhibitor. J Biol Chem. 1986 Jul 25;261(21):9727-31. [PubMed:3525533 ]
- Mikkelsen J, Hojrup P, Nielsen PF, Roepstorff P, Knudsen J: Amino acid sequence of acyl-CoA-binding protein from cow liver. Biochem J. 1987 Aug 1;245(3):857-61. doi: 10.1042/bj2450857. [PubMed:3663196 ]
- Jensen MS, Hojrup P, Rasmussen JT, Knudsen J: Purification and characterization of variants of acyl-CoA-binding protein in the bovine liver. Biochem J. 1992 Jun 15;284 ( Pt 3):809-12. doi: 10.1042/bj2840809. [PubMed:1622397 ]
- Hansen JS, Faergeman NJ, Kragelund BB, Knudsen J: Acyl-CoA-binding protein (ACBP) localizes to the endoplasmic reticulum and Golgi in a ligand-dependent manner in mammalian cells. Biochem J. 2008 Mar 15;410(3):463-72. doi: 10.1042/BJ20070559. [PubMed:17953517 ]
- Andersen KV, Poulsen FM: Three-dimensional structure in solution of acyl-coenzyme A binding protein from bovine liver. J Mol Biol. 1992 Aug 20;226(4):1131-41. doi: 10.1016/0022-2836(92)91057-v. [PubMed:1518047 ]
- Andersen KV, Poulsen FM: The three-dimensional structure of acyl-coenzyme A binding protein from bovine liver: structural refinement using heteronuclear multidimensional NMR spectroscopy. J Biomol NMR. 1993 May;3(3):271-84. doi: 10.1007/BF00212514. [PubMed:8358232 ]
- Kragelund BB, Andersen KV, Madsen JC, Knudsen J, Poulsen FM: Three-dimensional structure of the complex between acyl-coenzyme A binding protein and palmitoyl-coenzyme A. J Mol Biol. 1993 Apr 20;230(4):1260-77. doi: 10.1006/jmbi.1993.1240. [PubMed:8503960 ]
- van Aalten DM, Milne KG, Zou JY, Kleywegt GJ, Bergfors T, Ferguson MA, Knudsen J, Jones TA: Binding site differences revealed by crystal structures of Plasmodium falciparum and bovine acyl-CoA binding protein. J Mol Biol. 2001 May 25;309(1):181-92. doi: 10.1006/jmbi.2001.4749. [PubMed:11491287 ]
|
