| Identification |
|---|
| HMDB Protein ID
| HMDBP12634 |
| Secondary Accession Numbers
| None |
| Name
| Transcription factor asR4 |
| Synonyms
|
- Xenovulene A biosynthesis cluster protein R4
|
| Gene Name
| ASR4 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Transcription factor; part of the gene cluster that mediates the biosynthesis of xenovulene A, an unusual meroterpenoid that has potent inhibitory effects on the human gamma-aminobutyrate A (GABAA) benzodiazepine receptor. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Cellular Component |
| nucleus |
| Molecular Function |
| zinc ion binding |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| DNA binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 68986.295 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| A0A2U8U2L8 |
| UniProtKB/Swiss-Prot Entry Name
| ASR4_SARSH |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Bailey AM, Cox RJ, Harley K, Lazarus CM, Simpson TJ, Skellam E: Characterisation of 3-methylorcinaldehyde synthase (MOS) in Acremonium strictum: first observation of a reductive release mechanism during polyketide biosynthesis. Chem Commun (Camb). 2007 Oct 21;(39):4053-5. doi: 10.1039/b708614h. Epub 2007 Jul 25. [PubMed:17912413 ]
- Schor R, Schotte C, Wibberg D, Kalinowski J, Cox RJ: Three previously unrecognised classes of biosynthetic enzymes revealed during the production of xenovulene A. Nat Commun. 2018 May 17;9(1):1963. doi: 10.1038/s41467-018-04364-9. [PubMed:29773797 ]
- Thomas P, Sundaram H, Krishek BJ, Chazot P, Xie X, Bevan P, Brocchini SJ, Latham CJ, Charlton P, Moore M, Lewis SJ, Thornton DM, Stephenson FA, Smart TG: Regulation of neuronal and recombinant GABA(A) receptor ion channels by xenovulene A, a natural product isolated from Acremonium strictum. J Pharmacol Exp Ther. 1997 Aug;282(2):513-20. [PubMed:9262310 ]
- Fisch KM, Skellam E, Ivison D, Cox RJ, Bailey AM, Lazarus CM, Simpson TJ: Catalytic role of the C-terminal domains of a fungal non-reducing polyketide synthase. Chem Commun (Camb). 2010 Aug 7;46(29):5331-3. doi: 10.1039/c0cc01162b. Epub 2010 Jun 16. [PubMed:20552126 ]
|
