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Showing Protein C-type lectin domain family 7 member A (HMDBP12648)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP12648
Secondary Accession Numbers None
Name C-type lectin domain family 7 member A
Synonyms
  1. Beta-glucan receptor
  2. C-type lectin superfamily member 12
  3. Dendritic cell-associated C-type lectin 1
  4. DC-associated C-type lectin 1
  5. Dectin-1
Gene Name CLEC7A
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Lectin that functions as pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi (PubMed:11567029, PubMed:12423684). Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (By similarity). Enhances cytokine production in macrophages and dendritic cells (By similarity). Mediates production of reactive oxygen species in the cell (By similarity). Mediates phagocytosis of C.albicans conidia (PubMed:17230442). Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Induces phosphorylation of SCIMP after binding beta-glucans (By similarity).
Pathways
  • C-type lectin receptor signaling pathway
  • Neutrophil extracellular trap formation
  • Phagosome
  • Tuberculosis
Reactions Not Available
GO Classification
Biological Process
positive regulation of interleukin-10 production
positive regulation of cell migration
positive regulation of interleukin-8 production
positive regulation of cell proliferation
phagocytosis, recognition
inflammatory response
positive regulation of superoxide anion generation
positive regulation of interleukin-12 production
cell recognition
positive regulation of phagocytosis
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of nitric oxide biosynthetic process
positive regulation of peptidyl-tyrosine phosphorylation
innate immune response
positive regulation of interferon-gamma production
positive regulation of tumor necrosis factor production
carbohydrate mediated signaling
cellular response to molecule of fungal origin
defense response to protozoan
detection of fungus
detection of molecule of fungal origin
leukocyte activation involved in immune response
positive regulation of cell maturation
positive regulation of killing of cells of other organism
positive regulation of dendritic cell cytokine production
positive regulation of interleukin-2 production
positive regulation of lymphocyte activation
positive regulation of monocyte chemotactic protein-1 production
positive regulation of respiratory burst
positive regulation of stress-activated MAPK cascade
positive regulation of cytokine production involved in inflammatory response
positive regulation of wound healing
positive regulation of interleukin-1 beta production
positive regulation of interleukin-6 production
positive regulation of gene expression
positive regulation of protein complex assembly
T cell activation
Cellular Component
cell surface
cytoplasm
plasma membrane
integral to membrane
Molecular Function
pattern recognition receptor activity
metal ion binding
carbohydrate binding
(1->3)-beta-D-glucan binding
MHC protein binding
identical protein binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 201
Molecular Weight 27626.98
Theoretical pI 4.964
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 45-65;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9BXN2
UniProtKB/Swiss-Prot Entry Name CLC7A_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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