| Identification |
|---|
| HMDB Protein ID
| HMDBP12653 |
| Secondary Accession Numbers
| None |
| Name
| Putative N-acetyltransferase 8B |
| Synonyms
|
- Acetyltransferase 1
- Camello-like protein 2
- ATase1
|
| Gene Name
| NAT8B |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| May have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617). May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (PubMed:19011241). |
| Pathways
|
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| negative regulation of apoptotic process |
| gastrulation with mouth forming second |
| positive regulation of gene expression |
| amyloid fibril formation |
| amyloid-beta metabolic process |
| peptidyl-lysine N6-acetylation |
| Cellular Component |
| endoplasmic reticulum membrane |
| endoplasmic reticulum-Golgi intermediate compartment membrane |
| endoplasmic reticulum-Golgi intermediate compartment |
| integral to membrane |
| Molecular Function |
| N-acetyltransferase activity |
| lysine N-acetyltransferase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 227 |
| Molecular Weight
| 25365.31 |
| Theoretical pI
| 9.347 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9UHF3 |
| UniProtKB/Swiss-Prot Entry Name
| NAT8B_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Popsueva AE, Luchinskaya NN, Ludwig AV, Zinovjeva OY, Poteryaev DA, Feigelman MM, Ponomarev MB, Berekelya L, Belyavsky AV: Overexpression of camello, a member of a novel protein family, reduces blastomere adhesion and inhibits gastrulation in Xenopus laevis. Dev Biol. 2001 Jun 15;234(2):483-96. doi: 10.1006/dbio.2001.0261. [PubMed:11397015 ]
- Ko MH, Puglielli L: Two endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levels. J Biol Chem. 2009 Jan 23;284(4):2482-92. doi: 10.1074/jbc.M804901200. Epub 2008 Nov 14. [PubMed:19011241 ]
- Hahn Y, Lee B: Human-specific nonsense mutations identified by genome sequence comparisons. Hum Genet. 2006 Mar;119(1-2):169-78. doi: 10.1007/s00439-005-0125-6. Epub 2006 Feb 10. [PubMed:16395595 ]
- Mak AB, Pehar M, Nixon AM, Williams RA, Uetrecht AC, Puglielli L, Moffat J: Post-translational regulation of CD133 by ATase1/ATase2-mediated lysine acetylation. J Mol Biol. 2014 May 29;426(11):2175-82. doi: 10.1016/j.jmb.2014.02.012. Epub 2014 Feb 17. [PubMed:24556617 ]
|
